Results 41 to 50 of about 667,959 (331)

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

open access: yesMolecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice   +16 more
wiley   +1 more source

Decoherence benchmarking of superconducting qubits [PDF]

open access: yes, 2019
We benchmark the decoherence of superconducting qubits to examine the temporal stability of energy-relaxation and dephasing. By collecting statistics during measurements spanning multiple days, we find the mean parameters $\overline{T_{1}}$ = 49 $\mu$s ...
Bengtsson, Andreas   +6 more
core   +2 more sources

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

open access: yesMolecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg   +43 more
wiley   +1 more source

Methodical aspects of benchmarking using in Consumer Cooperatives trade enterprises activity [PDF]

open access: yesMarketing i Menedžment Innovacij, 2013
The aim of the article. The aim of this article is substantiation of benchmarking main types in Consumer Cooperatives trade enterprises activity; flashlighting of main advantages and drawbacks of benchmarking using; presentation of the authors view upon ...
Yu.V. Dvirko
doaj  

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

open access: yesMolecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix   +13 more
wiley   +1 more source

Benchmarking in cluster analysis: A white paper [PDF]

open access: yes, 2018
To achieve scientific progress in terms of building a cumulative body of knowledge, careful attention to benchmarking is of the utmost importance. This means that proposals of new methods of data pre-processing, new data-analytic techniques, and new ...
Boulesteix, Anne-Laure   +7 more
core   +4 more sources

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

open access: yesMolecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris   +10 more
wiley   +1 more source

RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects

open access: yesMolecular Oncology, EarlyView.
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley   +1 more source

A Roadmap for Migration System-Architecture Decision by Neutrosophic-ANP and Benchmark for Enterprise Resource Planning Systems

open access: yesIEEE Access, 2021
The selection of the system-architecture is critical step in software-engineering lifecycle. Unfortunately, the selecting a suitable architecture is a hard mission. The difficulty of the adopting architecture increases in inconsistence case as in SOA and
Amany A. Slamaa   +2 more
doaj   +1 more source

A Large-Scale Benchmark Dataset for Anomaly Detection and Rare Event Classification for Audio Forensics [PDF]

open access: gold, 2022
Ahmed Abbasi   +5 more
openalex   +1 more source

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