Results 71 to 80 of about 185,092 (310)

Unraveling 4‐Phenylbutyrate's Therapeutic Role in SLC6A1 Disorders: Pharmacochaperoning Over HDAC Inhibition

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Variants in SLC6A1, encoding the GABA transporter 1 (GAT‐1), cause epilepsy, autism spectrum disorder, and developmental delay via loss of GABA uptake, impaired trafficking, and ER retention. We previously found that 4‐Phenylbutyrate (PBA), an FDA‐approved drug, restores GABA uptake and reduces seizures in SLC6A1‐related disorders ...
Melissa B. DeLeeuw   +5 more
wiley   +1 more source

Plasma EV Proteomics Identifies ECM Remodeling and Inflammatory Proteins LUM and C7 as Candidate Biomarkers in FSHD

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Facioscapulohumeral muscular dystrophy (FSHD) is one of the most debilitating and common muscular dystrophies. Despite its severity, no approved therapy exists for FSHD patients. However, several therapeutic candidates are currently under development, and some have recently entered clinical trials, marking the need for reliable ...
Mustafa Bilal Bayazit   +11 more
wiley   +1 more source

Benchmarking logistischer Dienstleistungsprozesse

open access: yes, 2022
S.105-122Benchmarking als die Suche nach besten Praktiken, die zu Spitzenleistungen führen, ist laut einer aktuellen Studie von Bain & Company eines der weltweit am meisten genutzten Managementinstrumente.
Jehle, Franziska   +3 more
core   +1 more source

Evaluation of a Novel Electric Health Record Sidecar Application to Display Rheumatoid Arthritis Clinical Outcomes During Clinic Visits: Results of a Stepped‐Wedge Cluster Randomized Pragmatic Trial

open access: yesArthritis Care &Research, EarlyView.
Objective We developed a novel electronic health record sidecar application to visualize key rheumatoid arthritis (RA) outcomes, including disease activity, physical function, and pain, via a patient‐facing graphical interface designed for use during outpatient visits (“RA PRO dashboard”).
Gabriela Schmajuk   +16 more
wiley   +1 more source

BENCHMARKING - A VALID STRATEGY FOR THE LONG TERM? [PDF]

open access: yes
The present paper work deals with a popular method for developingrequirements and setting goals ââ¬â benchmarking. It contains general aspects about thispowerful performance improvement tool, including types of benchmarking, steps tofollow in ...
Larisa Dragolea, Denisa Cotirlea
core  

Factory Flow Benchmarking Report [PDF]

open access: yes, 1996
LAI benchmarked representative part fabrications and some assembly operations within its member companies of the defense aircraft industry. This paper reports the results of this benchmarking effort. In addition, this report explores the major components
Shields, Thomas J.
core  

Benchmarking '99

open access: yes, 2022
»Steigerung der Wettbewerbsfähigkeit privater und öffentlicher Unternehmen« ist das Motto der fünften Benchmarking-Tagung, die in Verbindung mit dem 3.
Kohl, H., Mertins, K.
core  

Prevalence of Systemic Lupus Erythematosus in Australia, 2010–2022: A Population‐Based Study Using Linked National Administrative Health Data

open access: yesArthritis Care &Research, EarlyView.
Objective Systemic lupus erythematosus (SLE) is a heterogenous inflammatory condition with widely varying global prevalence estimates. The frequency of SLE in the general population of Australia has been reported to be notably lower than contemporary estimates in countries such as the United States or United Kingdom, at 19 to 39 per 100,000 as opposed ...
Lucinda Roper   +7 more
wiley   +1 more source

BENCHMARKING FINANCIAL PERFORMANCE: A COMPARATIVE APPROACH [PDF]

open access: yesAnalele Universităţii Constantin Brâncuşi din Târgu Jiu : Seria Economie
The concept of benchmarking comes from English, it is also known as comparative performance analysis and represents a strategic and operational management method adopted by companies with the aim of improving performance.
ECOBICI MIHAELA LOREDANA
doaj  

Benchmarking the Benchmarks

open access: yesProceedings of the ACM Asia Conference on Computer and Communications Security, 2023
Marc Miltenberger   +3 more
openaire   +1 more source

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