Results 41 to 50 of about 790,699 (345)

FoxO1 signaling in B cell malignancies and its therapeutic targeting

FEBS Letters, EarlyView.
FoxO1 has context‐specific tumor suppressor or oncogenic character in myeloid and B cell malignancies. This includes tumor‐promoting properties such as stemness maintenance and DNA damage tolerance in acute leukemias, or regulation of cell proliferation and survival, or migration in mature B cell malignancies.
Krystof Hlavac, Petra Pavelkova, Laura Ondrisova, Marek Mraz   +3 more
wiley   +1 more source

Review of multilayer reinforced concrete beams with rectangular cross section experimental-theoretical studies

Збірник наукових праць: Серія: Галузеве машинобудування, будівництво
One of the options for reducing cement consumption for the preparation of concrete for bent reinforced concrete structures is the use of two-layer beams with higher strength concrete in the compressed zone and lower strength concrete in the tensile zone,
Дмитрій Романенко, Олександр Крупченко, Павло Юрко   +2 more
doaj   +1 more source

Deflection Ductility of Slabs Made of Hybrid Mesh-And-Fibre-Reinforced Cementbased Composite

Archives of Civil Engineering, 2017
Steel Mesh-Reinforced Cementitious Composites (SMRCC) (traditionally known as ferrocement) have been in existence for few decades, but have some limitations set on element thickness and number of reinforcing mesh layers and the resulting deflection ...
Sakthivel P. B.
doaj   +1 more source

Creating Elastic Organic Crystals of π-Conjugated Molecules with Bending Mechanofluorochromism and Flexible Optical Waveguide.

Angewandte Chemie, 2018
To create low band-gap, fluorescent, and elastic organic crystal emitters, we focused on an extended π-conjugated system based on: a) a planar conformation,b) a rigid structure, and c) controlled intermolecular interactions.
S. Hayashi, Shun Yamamoto, Daisuke Takeuchi, Y. Ie, Koji Takagi   +4 more
semanticscholar   +1 more source

The cytoskeletal control of B cell receptor and integrin signaling in normal B cells and chronic lymphocytic leukemia

FEBS Letters, EarlyView.
In lymphoid organs, antigen recognition and B cell receptor signaling rely on integrins and the cytoskeleton. Integrins act as mechanoreceptors, couple B cell receptor activation to cytoskeletal remodeling, and support immune synapse formation as well as antigen extraction.
Abhishek Pethe, Tanja Nicole Hartmann
wiley   +1 more source

Effect of Particle Size on Mechanical Properties of the Recycling Compact Disks Reinforced Epoxy [PDF]

Engineering and Technology Journal, 2018
The recycling of CDs or DVDs (compact disks) as a filler in polymer composites can be used in many engineering applications such as electrical, automobile, and building applications.
Shayma Ahmed
doaj   +1 more source

Exploring lipid diversity and minimalism to define membrane requirements for synthetic cells

FEBS Letters, EarlyView.
Designing the lipid membrane of synthetic cells is a complex task, in which its various roles (among them solute transport, membrane protein support, and self‐replication) should all be integrated. In this review, we report the latest top‐down and bottom‐up advances and discuss compatibility and complexity issues of current engineering approaches ...
Sergiy Gan, Victoria Scarpelli, Marten Exterkate   +2 more
wiley   +1 more source

Aspects of flexural behavior of high strength concrete elements with or without steel fibers [PDF]

Urbanism. Arhitectura. Constructii, 2013
Steel fiber reinforced high strength concrete (SFRHSC) is concrete made of hydraulic cements containing fine or fine and coarse aggregate and discontinuous discrete steel fibers. In tension, SFRHSC fails only after the steel fiber breaks or is pulled out
Gheorghe-Alexandru Bărbos
doaj  

C9orf72 ALS‐causing mutations lead to mislocalization and aggregation of nucleoporin Nup107 into stress granules

FEBS Letters, EarlyView.
Mutations in the C9orf72 gene represent the most common genetic cause of amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disease. Using patient‐derived neurons and C. elegans models, we find that the nucleoporin Nup107 is dysregulated in C9orf72‐associated ALS. Conversely, reducing Nup107 levels mitigates disease‐related changes.
Saygın Bilican, Yara Nabawi, William Hongyu Zhang, Dunja Petrovic, Markus Wehrmann, Sara Muñoz‐García, Seda Koyuncu, David Vilchez   +7 more
wiley   +1 more source

Genomics‐led approach to drug testing in models of undifferentiated pleomorphic sarcoma

Molecular Oncology, EarlyView.
GA text Genomic data from undifferentiated pleomorphic sarcoma patients and preclinical models were used to inform a targeted drug screen. Selected compounds were tested in 2D and 3D cultures of UPS cell lines. A combination of trametinib and infigratinib was synergistic in the majority of UPS cell lines tested, which was further confirmed in an ex ...
Piotr J. Manasterski, Molly R. Danks, John P. Thomson, Morwenna Muir, Martin Lee, John C. Dawson, Ana T. Amaral, Juan Diaz‐Martin, David S. Moura, Javier Martin‐Broto, Ali Alsaadi, Donald M. Salter, Ailsa J. Oswald, Graeme Grimes, Larry Hayward, Ted R. Hupp, Karen Sisley, Paul H. Huang, Neil O. Carragher, Valerie G. Brunton   +19 more
wiley   +1 more source