Results 41 to 50 of about 790,699 (345)
FoxO1 signaling in B cell malignancies and its therapeutic targeting
FoxO1 has context‐specific tumor suppressor or oncogenic character in myeloid and B cell malignancies. This includes tumor‐promoting properties such as stemness maintenance and DNA damage tolerance in acute leukemias, or regulation of cell proliferation and survival, or migration in mature B cell malignancies.
Krystof Hlavac+3 more
wiley +1 more source
One of the options for reducing cement consumption for the preparation of concrete for bent reinforced concrete structures is the use of two-layer beams with higher strength concrete in the compressed zone and lower strength concrete in the tensile zone,
Дмитрій Романенко+2 more
doaj +1 more source
Deflection Ductility of Slabs Made of Hybrid Mesh-And-Fibre-Reinforced Cementbased Composite
Steel Mesh-Reinforced Cementitious Composites (SMRCC) (traditionally known as ferrocement) have been in existence for few decades, but have some limitations set on element thickness and number of reinforcing mesh layers and the resulting deflection ...
Sakthivel P. B.
doaj +1 more source
To create low band-gap, fluorescent, and elastic organic crystal emitters, we focused on an extended π-conjugated system based on: a) a planar conformation,b) a rigid structure, and c) controlled intermolecular interactions.
S. Hayashi+4 more
semanticscholar +1 more source
In lymphoid organs, antigen recognition and B cell receptor signaling rely on integrins and the cytoskeleton. Integrins act as mechanoreceptors, couple B cell receptor activation to cytoskeletal remodeling, and support immune synapse formation as well as antigen extraction.
Abhishek Pethe, Tanja Nicole Hartmann
wiley +1 more source
Effect of Particle Size on Mechanical Properties of the Recycling Compact Disks Reinforced Epoxy [PDF]
The recycling of CDs or DVDs (compact disks) as a filler in polymer composites can be used in many engineering applications such as electrical, automobile, and building applications.
Shayma Ahmed
doaj +1 more source
Exploring lipid diversity and minimalism to define membrane requirements for synthetic cells
Designing the lipid membrane of synthetic cells is a complex task, in which its various roles (among them solute transport, membrane protein support, and self‐replication) should all be integrated. In this review, we report the latest top‐down and bottom‐up advances and discuss compatibility and complexity issues of current engineering approaches ...
Sergiy Gan+2 more
wiley +1 more source
Aspects of flexural behavior of high strength concrete elements with or without steel fibers [PDF]
Steel fiber reinforced high strength concrete (SFRHSC) is concrete made of hydraulic cements containing fine or fine and coarse aggregate and discontinuous discrete steel fibers. In tension, SFRHSC fails only after the steel fiber breaks or is pulled out
Gheorghe-Alexandru Bărbos
doaj
Mutations in the C9orf72 gene represent the most common genetic cause of amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disease. Using patient‐derived neurons and C. elegans models, we find that the nucleoporin Nup107 is dysregulated in C9orf72‐associated ALS. Conversely, reducing Nup107 levels mitigates disease‐related changes.
Saygın Bilican+7 more
wiley +1 more source
Genomics‐led approach to drug testing in models of undifferentiated pleomorphic sarcoma
GA text Genomic data from undifferentiated pleomorphic sarcoma patients and preclinical models were used to inform a targeted drug screen. Selected compounds were tested in 2D and 3D cultures of UPS cell lines. A combination of trametinib and infigratinib was synergistic in the majority of UPS cell lines tested, which was further confirmed in an ex ...
Piotr J. Manasterski+19 more
wiley +1 more source