Results 41 to 50 of about 516,104 (247)

Ionomycin suppresses cancer cell growth by disrupting mitochondrial transcription

FEBS Open Bio, EarlyView.
In this study, we identify a new function for the selective Ca2+ ionophore, ionomycin, as an inhibitor of mitochondrial transcription. Both total and nascent RNA analyses revealed that ionomycin treatment reduces the transcription of mitochondrial genes.
Lishen Wang, Mingqiang Deng, Dongmei He, Diqin Lai, Dongjun Liu, Dengyong Zhu, Zhenhua Zhang, Peng Tang, Chuanman Zhou, Menghui Yin, Xichen Bao   +10 more
wiley   +1 more source

Bending Tests of 40X13 (40Kh13) Steel Specimens after Laser Hardening and Alloying

Механика машин, механизмов и материалов
The behavior of flat specimens made of 40X13 (40Kh13) corrosion-resistant steel after laser hardening and laser alloying under bending loading was studied.
Andrey I. Verameichyk, Mikhail V. Neroda, Boris G. Kholodar, Maksim V. Kheuk   +3 more
doaj   +1 more source

Experimental and Numerical Investigation of Construction Defects in Reinforced Concrete Corbels

Buildings, 2023
Reinforced concrete corbels were examined in this study for the cracking behavior and strength evaluation, focusing on defects typically found in these structures.
Faisal Shabbir, Alireza Bahrami, Ibrar Ahmad, Nasim Shakouri Mahmoudabadi, Muhammad Iqbal, Afaq Ahmad, Yasin Onuralp Özkılıç   +6 more
doaj   +1 more source

From patient advocacy to patient‐driven research: Building active partnerships beginning at the bench to reach the bedside

FEBS Open Bio, EarlyView.
Research is strongest when conducted alongside patients, not just about them. Patient research organizations help integrate patient perspectives into research priorities, study design, and scientific meetings, leading to meaningful patient outcomes and development of relevant therapies.
Jenica H. Kakadia, Rachel Heilmann, Maximiliano Barrientos, Laura MacNeill, Ingrid Vallee, Sarah K. Schultz, Patrick O'Donoghue, Angelica A. Moresco, Victoria M. Siu, Ilka U. Heinemann   +9 more
wiley   +1 more source

Effect of die fillet radius on tube thinning in free bending

Scientific Reports
During the operation of a free-bending die, its fillets inevitably wear out, thereby reducing their “sharpness” and decreasing the forming accuracy of tubes.
Yaochen Lin, Yunfeng Lin, Weiming Lin, Heng Liu, Shuyou Zhang, Zhineng Wang   +5 more
doaj   +1 more source

Comparative Analysis of In-Plane and Out-of-Plane Bending Benchmarks Using Two Finite Element Packages

Applied Sciences
An essential aspect of design from the perspective of structural strength is the reliability of the results obtained during the computations for the analyzed model.
Emilia Słota, Adam Wosatko
doaj   +1 more source

TIMBER BEAM REPAIR BASED ON POLYMER-CEMENTITIOUS BLENDS [PDF]

Engenharia Agrícola, 2017
This study aims to manufacture and apply polymer-cementitious blends based on a combination of epoxy polymer and Ordinary Portland Cement (OPC) for timber beam repair.
André L. Christoforo, Tulio H. Panzera, Victor A. de Araujo, Juliano Fiorelli, Francisco A. R. Lahr   +4 more
doaj   +1 more source

Genetic dissection of human ABCE1 in yeast reveals separable requirements for ribosome recycling and suppression of aberrant reinitiation

FEBS Open Bio, EarlyView.
Human ABCE1 cannot functionally replace its yeast ortholog. Yeast–human chimera analysis identified NBD1 as a major interspecies barrier. Genetic screening yielded hABCE1 revertants that rescue yeast viability but fail to suppress aberrant translation reinitiation in the 3′ UTR.
Eriko Nakata, Yuxin Li, Kei Endo, Koichi Ito   +3 more
wiley   +1 more source

Green Retreats. Women, gardens and eighteenth-century culture

, 2013
Green Retreats presents a lively and beautifully illustrated account of eighteenth-century women in their gardens, in the context of the larger history of their retirement from the world – whether willed or enforced – and of their engagement with the ...
Bending, Stephen
core   +1 more source

Analysis of Mechanical Properties of Casted Aluminium Alloy for Automotive Safety Application

Engineering Proceedings
Automotive safety encompasses various measures, including seat belts, airbags, and advanced driver assistance systems, to minimise the risk of accidents and protect vehicle occupants.
Sourav, Somanagouda Patil, Naveen Chandra, Nithin Kumar, Dilip Kumar, Rashmi P. Shetty   +5 more
doaj   +1 more source