Results 111 to 120 of about 13,904 (260)

Napabucasin transforms liver microenvironment and boosts immunotherapy efficacy by converting potential metastases into “hot” tumors

Interdisciplinary Medicine, EarlyView.
Napabucasin reduces liver metastases by reprogramming the hepatic microenvironment. It induces hepatocyte secretion of CCL21 via c‐Fos activation, recruiting lymphocytes and converting “cold” metastases into immunologically “hot” tumors. This effect is liver‐specific and independent of cancer cells.
Qiongqiong Wang, Jiaqi Zhou, Hang Qiao, Yifan Jia, Ling Ye, Zeli Li, Jiahe Ouyang, Haoxian Zhou, Kangxin Zeng, Xuemeng Wang, Yixian Wang, Yang Zhang, Yupeng Zhang, Yizhou Cai, Yutao Hu, Minzhe Zhang, Wenwei Xu, Zhenzhen Wu, Xiaofang Qiu, Li Lin   +19 more
wiley   +1 more source

Soft Power in Trade: Quantifying the Impact of Confucius Institutes on China's Exports

International Studies of Economics, EarlyView.
ABSTRACT This paper investigates the role of Confucius Institutes (CIs) as a form of China's cultural diplomacy and their impact on international trade, particularly exports. Using a gravity model, we analyze data from 1990 to 2019 across countries, finding that the presence of CIs significantly boosts China's exports.
Renjing Chen, Wei Jin, Tangrui Yang
wiley   +1 more source

Uncertain use of a fixed p value significance threshold in randomized clinical trials. [PDF]

Trials
Habibzadeh F.
europepmc   +1 more source

Two Problems for the Political Inclusion of Animals

Journal of Applied Philosophy, EarlyView.
ABSTRACT In recent years, the field of animal ethics has taken a political turn, with scholars arguing that sentient nonhuman animals should be included in the political sphere. This article explores two key challenges arising from this turn towards the political inclusion of animals: the Conflict Problem and the Numbers Problem.
David Paaske, Angela K. Martin
wiley   +1 more source

Will I Regret This? Should I Care? On Regret and Wellbeing

Journal of Applied Philosophy, EarlyView.
ABSTRACT Regret colours many areas of our lives, from the vital to the trivial. One example is in medical decision‐making, when physicians hesitate to provide procedures they think their patients will regret. For instance, physicians sometimes refuse younger women's requests for elective sterilization. Hesitating when we believe that we or someone else
Alyssa Izatt
wiley   +1 more source

Navigating ethical considerations and challenges in medical education research. [PDF]

Korean J Med Educ
Htay MNN, Marzo RR, Abas AL.
europepmc   +1 more source

Visual Patterns of Diaphragmatic Motion in Acute Respiratory Failure: A Prospective Pilot Study

Journal of Clinical Ultrasound, Volume 53, Issue 3, Page 421-428, March/April 2025.
In this prospective bicentric study, we studied the relationship between the appearance of diaphragmatic motion and the etiological diagnosis of patients admitted to the emergency department with ARF. We observed a different visual pattern in patients with pneumonia. This is an interesting result as it allows the diagnosis of pneumonia without the need
Thibaut Markarian, Matthieu Daniel, Kevin Guillemet, Florian Ajavon, Florent Femy, Romain Genre Grandpierre, Anne‐Laure Feral‐Pierssens, Xavier Bobbia   +7 more
wiley   +1 more source

Volume without Value: The Empty Metrics of Pain Medicine Social Media Influence. [PDF]

J Pain Res
Pritzlaff SG, Singh N, Schatman ME, Flower V, Sheth SJ.   +4 more
europepmc   +1 more source

Young people's lived experience expertise: Insights from the DigiCAT project to develop a counterfactual analysis tool for mental health data

JCPP Advances, EarlyView.
In our project to develop a digital tool for counterfactual analysis, with an emphasis on researching active ingredients for adolescent mental health, we incorporated lived experience expertise across the lifecycle of tool development and dissemination.
Marie Allitt, Helen Wright, Aja Murray, Ingrid Obsuth   +3 more
wiley   +1 more source

Screening for diabetes mellitus type 1 in the pediatric general population: an ethical analysis. [PDF]

Eur J Pediatr
Lechsner P, Holl RW, Steger F.
europepmc   +1 more source