Results 91 to 100 of about 332,234 (284)

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

A study of the practices and processes and benefit sharing of limestone mining in the Banour-Shiva Mining Region in Himachal Pradesh, India

Environmental & Socio-economic Studies, 2020
Mining is essentially an important income generating activity in the developing countries of the world. This is beneficial for their social and economic development and thus developing countries place a great dependence on their exploitation of mineral ...
Nath Swami, Singh Ranveer
doaj   +1 more source

Learning from farmer-led access and benefit sharing. Conclusions. [PDF]

, 2016
This special issue of Farming Matters magazine has explored the ways in which access and benefit sharing of plant genetic resources can work for family farmers.
Bruil, J., Pistorius, R., Vernooy, Ronnie   +2 more
core  

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

REDD-based Offsets: Benefit Sharing and Risks [PDF]

, 2015
In this study we apply systems analysis methods to modeling financial instruments supporting the Reduced Emissions from Deforestation and Degradation (REDD) program.
Khabarov, N., Krasovskii, A., Obersteiner, M.   +2 more
core  

a community forest case-study in Tanzania [PDF]

, 2010
The current debate on climate change, especially with respect to the role of REDD projects and the push for the recognition of community (participatory) forest management as a carbon mitigation option represents a potential for communities to receive ...
Re, Riccardo da, Secco, Laura, Tassa, Dominic T.   +2 more
core   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

Convention on Biological Diversity (CBD) and the Nagoya Protocol: Implications and Compliance Strategies for the Global Coffee Community

Foods
The Nagoya Protocol on Access and Benefit-sharing (ABS) of the Convention on Biological Diversity (CBD) is a fundamental international agreement that plays a crucial role in the protection and equitable utilization of plant genetic resources.
Dirk W. Lachenmeier, Christophe Montagnon   +1 more
doaj   +1 more source

Access and benefit sharing in participatory plant breeding in Southwest China [PDF]

, 2016
This article discusses access and benefit sharing within the context of participatory plant breeding. It presents how Chinese farmers and breeders collaborate in relation to crop improvement and on-farm maintenance of plant genetic resources.
Song, X., Song. Y., Vernooy, Ronnie, Zhang, Y.   +3 more
core