Results 101 to 110 of about 332,234 (284)

Access to and benefit sharing of plant genetic resources: novel field experiences to inform policy [PDF]

, 2013
A number of national and international policy processes are underway to allow for the development of sui generis systems to protect local natural and genetic resources and related knowledge about their management, use and maintenance.
Ruiz, M., Vernooy, Ronnie
core   +2 more sources

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

Bioeconomic Model of Community Incentives for Wildlife Management Before and After CAMPFIRE [PDF]

This paper formulates a bioeconomic model to analyze community incentives for wildlife management under benefit-sharing programs like the Communal Areas Management Programme for Indigenous Resources (CAMPFIRE) in Zimbabwe.
Fischer, Carolyn, Muchapondwa, Edwin, Sterner, Thomas   +2 more
core  

Multilevel governance challenges in transitioning towards a national approach for REDD+:Evidence from 23 subnational REDD+ initiatives [PDF]

, 2015
Although REDD+ was conceived as a national approach to reducing emissions from deforestation and forest degradation, many of the early advances have been at the subnational level. It is critical to link these subnational efforts to emerging national REDD+
Duchelle, Amy E, Gozales Tovar, Jazmin, Larson, Anne M, Myers, Rodd, Ravikumar, Ashwin   +4 more
core   +3 more sources

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Benefit Sharing Governance Framework: Pathways for Financial Benefit Sharing in Traditional Communities

Sustainability
This article proposes the creation of a participatory governance framework for traditional communities, focusing on financial benefits sharing, whether they come from compensation, indemnification, or socio-environmental projects. The proposed governance framework was developed based on a series of governance principles and the perceptions and needs of
Angelo de Sousa Santarlacci, Humberto Angelo, Álvaro Nogueira de Souza, Maria de Fátima de Brito Lima, Maísa Santos Joaquim, Eder Pereira Miguel, Júlia de Oliveira Carneiro   +6 more
openaire   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Benefit Sharing at Scale

, 2019
Land use initiatives that distribute result-based payments for emission reductions need to define transparent and equitable benefit-sharing plans for how these incentives flow to a diverse range of stakeholders. This study synthesizes good practices for benefit sharing in jurisdictional land use programs that make results-based payments for emission ...
openaire   +3 more sources

Techniksoziologische Betrachtung des Cost Benefit Sharing am Beispiel eines Lufttransportnetzes [PDF]

, 2008
Die Modellierung Großer Netz der Logistik im Sonderforschungsbereich 559 zielt darauf, die Komplexität logistischer Prozesse zu reduzieren (Kuhn 1994). Der Fokus der Abbildung, Analyse und Optimierung von Logistikprozessen liegt dabei auf der Gestaltung ...
Cramer, Stephan, Hertelendy, Tibor, Sieke, Harald   +2 more
core  

Mare Geneticum : Balancing Governance of Marine Genetic Resources in International Waters [PDF]

, 2018
Peer reviewedPublisher ...
Broggiato, Arianna, Burton, Geoff, Jaspars, Marcel, Lallier, Laura E., Muyldermans, Dominic, Vanagt, Thomas   +5 more
core   +2 more sources