Results 51 to 60 of about 1,862,201 (299)

The UN in the lab [PDF]

open access: yes, 2014
We consider two alternatives to inaction for governments combating terrorism, which we term Defense and Prevention. Defense consists of investing in resources that reduce the impact of an attack, and generates a negative externality to other governments,
A Rapoport   +40 more
core   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Benefit and Cost Analysis of Resource Sharing

open access: yesInternational Journal of Librarianship
Libraries are not exempt from rising costs. The situation presented is how libraries can continue to provide services while also finding efficiencies in labor and operational expenditures.
Cherie Weible, Janelle Sander
doaj   +1 more source

Low-Income Subsidies for the Medicare Prescription Drug Benefit: The Impact of the Asset Test [PDF]

open access: yes, 2005
Assesses the impact of the requirement that low-income individuals with Medicare meet an asset test in order to receive additional help paying premiums and cost sharing under the new Medicare drug benefit.
Katherine A. Desmond, Thomas Rice
core  

Aggressive prostate cancer is associated with pericyte dysfunction

open access: yesMolecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero   +11 more
wiley   +1 more source

How Baywide Nutrient Trading Could Benefit Pennsylvania Farms [PDF]

open access: yes, 2010
Outlines how legislation to make the Chesapeake Bay watershed healthier, including a program allowing farms that reduce runoff of nutrients to below target to sell "credits," would benefit Pennsylvania farms through cost-sharing funds and new ...
Cy Jones   +4 more
core  

Latent Multi-task Architecture Learning

open access: yes, 2018
Multi-task learning (MTL) allows deep neural networks to learn from related tasks by sharing parameters with other networks. In practice, however, MTL involves searching an enormous space of possible parameter sharing architectures to find (a) the layers
Augenstein, Isabelle   +3 more
core   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

open access: yesMolecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed   +10 more
wiley   +1 more source

Mobilizing Benefit-Sharing Through Transportation Infrastructure: Informal Roads, Extractive Industries and Benefit-Sharing in the Irkutsk Oil and Gas Region, Russia

open access: yesResources, 2020
Road infrastructure development is an existing, but not a frequent element of extractive industry benefit-sharing frameworks in remote northern regions.
Vera Kuklina   +3 more
doaj   +1 more source

Quantifying the benefits of vehicle pooling with shareability networks [PDF]

open access: yes, 2014
Taxi services are a vital part of urban transportation, and a considerable contributor to traffic congestion and air pollution causing substantial adverse effects on human health.
Ratti, Carlo   +5 more
core   +2 more sources

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