Results 221 to 230 of about 4,574,160 (318)

Linking digital teaching management platform quality to perceived net benefits: a hybrid SEM-LPA study in university sports club-based teaching. [PDF]

Front Psychol
Liu J, Zhang Z.
europepmc   +1 more source

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

Landscape extraordinariness and visitors' psychological restoration in national park settings: a chain mediation model of awe, construal level, and connectedness to nature. [PDF]

Front Psychol
Zhu Z, Zhang J, Chen X, Li A, Song H.
europepmc   +1 more source

Long‐Term Follow‐Up of Chemotherapy‐Associated Biological Aging in Women With Early Breast Cancer

Aging and Cancer, EarlyView.
Women threated with adjuvant chemotherapy for early breast cancer have sustained long‐term increase in p16INK4a,, a robust marker of cell senescence, suggesting a chemotherapy‐associated age acceleration. p16INK4a as well as other biomarkers may identify patients at greatest risk for senescence‐related diseases of aging.
Hyman B. Muss, Alexis C. Wardell, Allison M. Deal, Kirsten A. Nyrop, Allison Ross, Yara G. Abdou, Jeffrey D. Aldrich, Lisa A. Cary, E. Claire Dees, Katherine E. Reeder‐Hayes, Emily M. Ray, Natalia Mitin, Denis Tsygankov   +12 more
wiley   +1 more source

Impact evaluation of the Hypertension Treatment in Nigeria program using the Translational Science Benefits Model. [PDF]

J Clin Transl Sci
Iyer G, Ripiye N, Orji IA, Shedul GL, Shedul GJ, Ugwuneji EN, Ojo TM, Okpetu E, Osagie S, Kandula N, Toma MM, Oshundele BR, Eze SV, Jamro EL, Obiezu-Umeh C, Baldridge AS, Hirschhorn LR, Ojji DB, Huffman MD.   +18 more
europepmc   +1 more source

Risk Prediction Models for Recurrence After Curative Treatment of Early‐Stage or Locally Advanced Lung Cancer: A Systematic Review

Aging and Cancer, EarlyView.
This systematic review synthesizes prognostic models for survival and recurrence in resected non‐small cell lung cancer. While many models demonstrate moderate to good discrimination, few are externally validated and reporting quality is variable, limiting clinical applicability and highlighting the need for robust, transparent model development ...
Evangeline Samuel, S. Tissera, E. Paul, J. Zalcberg, R. G. Stirling   +4 more
wiley   +1 more source

Patients' Perspectives on Applications of AI and Personalized Medicine in Life-Threatening Heart Disease: European Cross-Sectional Patient Questionnaire Study. [PDF]

J Med Internet Res
Lindinger GL, Schiermeier NJ, Willems DL, Maris MT, Khattab M, Tan HL, Henzler D, Bak MAR, Nagel E, Lauerer M.   +9 more
europepmc   +1 more source

Annual Report of the State Health Benefits Program of New Jersey, June 30, 2015 and 2014

, 2015
State Health Benefits Program of New Jersey
core  

Five‐Year Outcomes of Laparoscopic Sphincter‐Preserving Surgery for Rectal Cancer: A Prospective Study in Elderly Vietnamese Patients

Aging and Cancer, EarlyView.
This prospective study demonstrates that laparoscopic sphincter‐preserving surgery is feasible for elderly patients. While overall survival reaches 70% at 5 years, advanced T‐stage and the omission of neoadjuvant therapy significantly drive recurrence, highlighting the need for personalized geriatric protocols despite logistical challenges.
Huu Duc Ho, Quang Le, Ngoc Thach Tran, Van Viet Ung, Loc Vu   +4 more
wiley   +1 more source