Results 51 to 60 of about 967,448 (308)

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Prevalence of Head and Neck Tumors in Children under 12 Years of Age Referred to the Pathology Department of Children’s Hospital in Tabriz during a 10-year Period

Journal of Dental Research, Dental Clinics, Dental Prospects, 2015
Background and aims. Head and neck tumors are the most common complaints of people referring to different medical sections, especially in children. The aim of this study was to evaluate the prevalence of these tumors in children less than 12 years of age
Shirin Fattahi, Sepideh Vosoughhosseini, Monir Moradzadeh Khiavi, Seyed Mostafa Mahmoudi, Parya Emamverdizadeh, Seyed Gholamreza Noorazar, Neda Yasamineh, Rana Lotfi   +7 more
doaj   +1 more source

Case Reports: Management Challenges in Pediatric Germ Cell Tumors

Frontiers in Pediatrics, 2021
Germ cell tumors in infants are most frequently extragonadal, benign, and amenable to surgical resection. An unusual feature of germ cell tumors is the potential coexistence of malignant with benign disease which makes it possible for patients with ...
Sophie Carr, Sophie Carr, Arash Safavi, Erik D. Skarsgard   +3 more
doaj   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

The Appearance of Benign Primary Bone Tumors on SPECT/CT

, 2023
Although bone scintigraphy has a low degree of specificity, it is a sensitive method for detecting abnormal bone mineralization. When used on cancer patients as well as those being evaluated for benign bone diseases, SPECT/CT has greatly increased the ...
Javed, Imran
core  

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Intravoxel incoherent motion combined with conventional MRI for the differentiation of benign, intermediate, and malignant fibrous soft-tissue tumors

Frontiers in Oncology
BackgroundFibroblastic/myofibroblastic tumors are among the most common soft-tissue tumors (STTs) encountered clinically. Several magnetic resonance imaging (MRI) features associated with malignant tumors overlap with benign tumors, making differential ...
Yue Dai, Yue Dai, Yuhan Long, Yuhan Long, Jie Zhou, Jie Zhou, Juan Tao, Wenjia Wang, Yifeng Zhu, Kai Zhang   +9 more
doaj   +1 more source

Treatment strategy for benign nerve tumors [PDF]

, 2020
Introduction: Peripheral nerve tumors are usually benign, rare, slow-growing and little symptomatic. The objective is to describe strategies for the diagnosis and treatment of patients with benign tumors of the ulnar nerve.
Katia Torres Batista, Valney Claudino Sampaio Martins, Ulises Prieto Y-Schwartzman, Rogerio Santos Silva, Carolina Zampronha Correia, Camila Freire Parente Alves da Silva, Isabel Cristina Correia   +6 more
core   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Leiomyoma of the epididymis treated with partial epididymectomy

Urology Annals, 2014
Tumors of the epididymis are very rare, they are both primary and secondary and whether the benign or malignant. Adenomatoid tumors and leiomyoma are the most frequently diagnosed benign tumors of the epididymis. Leiomyomas are benign, often bulky tumors
Basri Cakiroglu, Faruk Ozcan, Lora Ates, Suleyman Hilmi Aksoy   +3 more
doaj   +1 more source