Results 131 to 140 of about 236,374 (260)

Cardiovascular Exercise Drives Neuroprotection in a Mouse Model of Spinocerebellar Ataxia 1 Via Rescue of Aberrant Splicing

open access: yesAnnals of Neurology, EarlyView.
Objective Spinocerebellar ataxia 1 (SCA1) is a fatal hereditary neurodegenerative disorder with no approved therapies, and gene‐targeting strategies have thus far failed in clinical trials. Exercise remains the only intervention shown to provide clinical benefit in patients with spinocerebellar ataxias (SCAs), yet the underlying mechanisms remain ...
Isabel Soto   +12 more
wiley   +1 more source

Tunable Regional Targeting of Self‐Assembling Peptide Nanomaterials in Acute Myocardial Infarction

open access: yesAdvanced NanoBiomed Research, EarlyView.
In a rat model of acute myocardial infarction, intravascular delivery of peptide nanofibers with a collagen‐targeting peptide bound to the infarct vasculature while globular peptide nanoparticles penetrated into the infarct area. This study demonstrated that size, shape, and surface chemistry of nanomaterials control the delivery location within the ...
Alexander Chen   +14 more
wiley   +1 more source

Metal–Phenolic Coatings Enable Universal Design of Spherical Nucleic Acids

open access: yesAngewandte Chemie, EarlyView.
A general and straightforward strategy for constructing spherical nucleic acids (SNAs) using metal–phenolic (MP) coatings has been developed. The resulting MP‐SNAs exhibit many of the hallmark SNA properties, including enhanced cellular uptake, and serve as versatile building blocks for the programmable assembly of a diverse library of nanoparticles ...
Chaojian Chen   +5 more
wiley   +2 more sources

ECG-Facilitated Detection of Light Chain Cardiac Amyloidosis in Long-Standing MGUS. [PDF]

open access: yesJACC Case Rep
Piwowarski J   +4 more
europepmc   +1 more source

Temperature‐ and Light‐Regulated Liquid Crystal Smart Window for Dynamic Control of Daylight and Solar Heat in All‐Weather Conditions

open access: yesAngewandte Chemie, EarlyView.
An environmentally adaptive smart window based on the interplay of light‐driven molecular motors and liquid crystal (LC) polymers is developed. The window can dynamically switch among three distinct working states: transparent, reflective, and scattering, depending on ambient temperature and solar light intensity, enabling excellent modulation of ...
Yang Zhang   +6 more
wiley   +2 more sources

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