Results 211 to 220 of about 247,029 (293)

The Chemistry and Biology of the Tetrodotoxin Natural Product Family

open access: yesAngewandte Chemie International Edition, Accepted Article.
Tetrodotoxin is a neurotoxic marine alkaloid, first isolated in 1909 from pufferfish and named after the biological order tetraodontiformes. Since its structural elucidation in 1964, it has attracted the interest of synthetic organic chemists due to its exceptional polarity, complex architecture, and important biological activity.
Benedikt Nißl   +6 more
wiley   +1 more source

Imaging‐Based High‐Content Screening with Clickable Probes Identifies XPB Inhibitors

open access: yesAngewandte Chemie International Edition, Accepted Article.
High‐content screening (HCS) has become a powerful tool in drug discovery; however, its reliance on indirect readouts and surrogate markers limits HCS’s ability to directly assess drug‐protein interactions at endogenous levels, particularly in subcellular contexts.
Shuqi Li   +10 more
wiley   +1 more source

Beating the Odds: A Successful Pregnancy in a Patient With ALK-Rearranged Lung Cancer on Alectinib. [PDF]

open access: yesCase Rep Med
Yeo N   +10 more
europepmc   +1 more source

Enhancing Multicenter Trials With the Trial Innovation Network's Initial Consultation Process.

open access: yesJAMA Netw Open
Harris PA   +44 more
europepmc   +1 more source

Crystal deposition triggers tubule dilation that accelerates cystogenesis in polycystic kidney disease. [PDF]

open access: yesJ Clin Invest
Torres JA   +12 more
europepmc   +1 more source

Author Correction: Disruption of neural periodicity predicts clinical response after deep brain stimulation for obsessive-compulsive disorder. [PDF]

open access: yesNat Med
Provenza NR   +25 more
europepmc   +1 more source

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