Genome Mining Discovery of a New Benzazepine Alkaloid Pseudofisnin A from the Marine Fungus Neosartorya pseudofischeri F27-1 [PDF]
Antibiotics, 2022 l-Kynurenine (Kyn) is an intermediate in the kynurenine pathway and is also found to be a building block or biosynthetic precursor to bioactive natural products.
Xiao-Xin Xue, Lin Chen, Man-Cheng Tang
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Cellular Physiology and Biochemistry, 2021 BACKGROUND/AIMS The NMDA receptor plays a key role in the pathogenesis of neurodegenerative disorders including Alzheimer's and Huntington's disease, as well as depression and drug or alcohol dependence. Due to its participation in these pathologies, the
Nadine Ritter +6 more
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The ultra-potent and selective TLR8 agonist VTX-294 activates human newborn and adult leukocytes. [PDF]
PLoS ONE, 2013 Newborns display distinct immune responses that contribute to susceptibility to infection and reduced vaccine responses. Toll-like receptor (TLR) agonists may serve as vaccine adjuvants, when given individually or in combination, but responses of ...
David J Dowling +7 more
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Candidate 3-benzazepine-1-ol type GluN2B receptor radioligands (11C-NR2B-Me enantiomers) have high binding in cerebellum but not to σ1 receptors [PDF]
EJNMMI Research, 2023 Key points Question: Do GluN2B radioligands 11C-NR2B-Me enantiomers show cross-binding with σ1 receptors in brain in vivo? Pertinent findings: 11C-(+)-NR2B-Me, 11C-(−)-NR2B-Me, 11C-(S)-NR2B-SMe, and 11C-(R)-NR2B-SMe give specific signals in whole rat ...
Lisheng Cai +9 more
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Identification and Preclinical Evaluation of a Radiofluorinated Benzazepine Derivative for Imaging the GluN2B Subunit of the Ionotropic NMDA Receptor [PDF]
Journal of Nuclear Medicine, 2018 The previously reported 11C-labeled GluN2B PET radioligand 11C-Me-NB1 served as a starting point for derivatization and led to the successful development of a radiofluorinated analog designated (R)-18F-OF-Me-NB1.
Ahmed Haider +10 more
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Four related benzazepine derivatives in a reaction pathway leading to a benzazepine carboxylic acid : hydrogen-bonded assembly in zero, one, two and three dimensions [PDF]
Acta Crystallographica Section C Structural Chemistry, 2014 The authors thank ‘Centro de Instrumentacion Cientıfico-Tecnica of Universidad de Jaen’ and the staff for data collection. AP, SAG and CMS thank Colciencias for financial support (grant No. 1102–521–28229). JC thanks the Consejerıa de Innovacion, Ciencia
Cobo, J. +4 more
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Recent Progress on the Synthesis of Benzazepine Derivatives via Radical Cascade Cyclization Reactions [PDF]
Youji huaxue, 2022 Qian Xiao +2 more
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Crystal structure of 4,5-dihydro-6H-tetrazolo[1,5-a]-1-benzazepine, C10H10N4 [PDF]
Zeitschrift für Kristallographie - New Crystal Structures, 1999 Rajnikant +5 more
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Synthesis and biological evaluation of chemokine receptor ligands with 2-benzazepine scaffold
European journal of medicinal chemistry, 2017 Simone Thum +13 more
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Strategic Methodologies for Efficient Synthesis of Imidazo[1,5‑a]pyridine and Benzazepine Analogs via the Unique Ritter-Type Reaction [PDF]
ACS Organic & Inorganic AuGunniga Tanomsiri +5 more
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