Results 1 to 10 of about 1,521 (150)
Neurobehavioral phenotyping of Gaq knockout mice reveals impairments in motor functions and spatial working memory without changes in anxiety or behavioral despair [PDF]
Frontiers in Behavioral Neuroscience, 2012 Many neurotransmitters, hormones and sensory stimuli elicit their cellular responses through the targeted activation of receptors coupled to Gq family heterotrimeric G proteins.
Aliya L Frederick +6 more
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Photocatalytic C-N addition amination of olefin [PDF]
E3S Web of Conferences, 2020 Amines widely exist in nature, wherein some of cyclic amines have crucially biological and physiological activities. They are also the basic blocks for the syntheses of important intermediates, raw materials or fine chemicals such as pharmaceuticals ...
Zhu Shihao, Chen Keran, Zhou Xinrui
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Antibiotics, 2022 l-Kynurenine (Kyn) is an intermediate in the kynurenine pathway and is also found to be a building block or biosynthetic precursor to bioactive natural products.
Xiao-Xin Xue, Lin Chen, Man-Cheng Tang
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Molecules, 2023 The 1-phenylbenzazepine template has yielded a number of D1R-like ligands, which, though useful as pharmacological tools, have significant drawbacks in terms of selectivity versus D5R as well as pharmacokinetic behavior.
Rajan Giri +3 more
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Inorganics, 2023 A series of latonduine derivatives, namely 11-nitro-indolo[2,3-d]benzazepine-7-(1-amino-hydantoin) (B), triazole-fused indolo[2,3-d]benzazepine-based Schiff bases HL1 and HL2 and metal complexes [M(p-cymene)(HL1)Cl]Cl, where M = Ru (1), Os (2), and [Cu ...
Christopher Wittmann +5 more
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Chiral Ligands Based on Binaphthyl Scaffolds for Pd-Catalyzed Enantioselective C–H Activation/Cycloaddition Reactions [PDF]
, 2022 info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/REDES METAL-ORGANICAS PARA LA VALORIZACION DE BIOMASA A TRAVES DE SIMULACIONES DE SISTEMAS CATALITICOSWe report the first examples of the use of ...
González González, José Manuel +4 more
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Synthesis of Indole‐Fused 1,4‐Diazepinones via Photoredox‐Catalyzed Cascade Cyclization Reaction
Advanced Synthesis &Catalysis, Volume 365, Issue 22, Page 3958-3966, November 21, 2023., 2023 Abstract A photoredox‐promoted approach for the synthesis of [1,4]diazepino[1,7‐a]indol‐6(7H)‐ones starting from N‐indolyl phenylacrylamides and aroyl chlorides as radical source is reported. This method, that involves a cascade radical addition on C−C double bond followed by intramolecular cyclization at indole C2‐position, affords two diastereomeric ...
Elisa Brambilla +6 more
wiley +1 more source
Asymmetric Catalytic Transformations of Aza‐ortho‐ and Aza‐para‐Quinone Methides
ChemCatChem, Volume 15, Issue 13, July 7, 2023., 2023 Aza‐quinone methides (aza‐QMs) are transient intermediates, which are able to react easily with a variety of nucleophiles providing a variety of N‐heterocycles. The catalytic methodologies for the derivatization of aza‐QM into chiral derivatives have been recently reported and involve organocatalytic or organometallic approaches.
Mercedes Zurro, Aitor Maestro
wiley +1 more source
Iodine(III)‐Mediated Oxidation of Anilines to Construct Dibenzazepines**
Chemistry – A European Journal, Volume 29, Issue 37, July 3, 2023., 2023 Cyclization: A mild, room temperature oxidative cyclization of 2‐substituted anilines that accesses a broad range of medium‐ring N‐heterocycles via radical intermediates is reported. Abstract The development of an efficient process that produces bioactive medium‐sized N‐heterocyclic scaffolds from 2‐substituted anilines using either iodosobenzene or ...
Carmen Margaret White +3 more
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Beilstein Journal of Organic Chemistry, 2022 Paullone isomers are known as inhibitors of tubulin polymerase and cyclin dependent kinases (Cdks), which are potential targets for cancer chemotherapy.
Irina Kuznetcova +4 more
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