Results 21 to 30 of about 5,260 (223)

SKF83959, an agonist of phosphatidylinositol-linked D(1)-like receptors, promotes ERK1/2 activation and cell migration in cultured rat astrocytes. [PDF]

PLoS ONE, 2012
Extracellular signal-regulated kinase 1/2 (ERK1/2) is a member of the mitogen-activated protein kinase family. It can mediate cell migration. Classical dopamine receptor-mediated ERK1/2 phosphorylation is widely studied in neurons.
Chao Huang, Jingjing Wu, Rujia Liao, Wei Zhang   +3 more
doaj   +1 more source

Synthesis of Indole‐Fused 1,4‐Diazepinones via Photoredox‐Catalyzed Cascade Cyclization Reaction

Advanced Synthesis &Catalysis, Volume 365, Issue 22, Page 3958-3966, November 21, 2023., 2023
Abstract A photoredox‐promoted approach for the synthesis of [1,4]diazepino[1,7‐a]indol‐6(7H)‐ones starting from N‐indolyl phenylacrylamides and aroyl chlorides as radical source is reported. This method, that involves a cascade radical addition on C−C double bond followed by intramolecular cyclization at indole C2‐position, affords two diastereomeric ...
Elisa Brambilla, Silvia Meraviglia, Edoardo Moneta, Donatella Nava, Silvia Rizzato, Giorgio Abbiati, Valentina Pirovano   +6 more
wiley   +1 more source

Asymmetric Catalytic Transformations of Aza‐ortho‐ and Aza‐para‐Quinone Methides

ChemCatChem, Volume 15, Issue 13, July 7, 2023., 2023
Aza‐quinone methides (aza‐QMs) are transient intermediates, which are able to react easily with a variety of nucleophiles providing a variety of N‐heterocycles. The catalytic methodologies for the derivatization of aza‐QM into chiral derivatives have been recently reported and involve organocatalytic or organometallic approaches.
Mercedes Zurro, Aitor Maestro
wiley   +1 more source

Four related benzazepine derivatives in a reaction pathway leading to a benzazepine carboxylic acid : hydrogen-bonded assembly in zero, one, two and three dimensions [PDF]

, 2014
The authors thank ‘Centro de Instrumentacion Cientıfico-Tecnica of Universidad de Jaen’ and the staff for data collection. AP, SAG and CMS thank Colciencias for financial support (grant No. 1102–521–28229). JC thanks the Consejerıa de Innovacion, Ciencia
Cobo, J., Glidewell, C., Guerrero, S.A., Palma, A., Sanabría, C.M.   +4 more
core   +2 more sources

Food-induced behavioral sensitization, its cross-sensitization to cocaine and morphine, pharmacological blockade, and effect on food intake [PDF]

, 2006
Repeated administration of abused drugs sensitizes their stimulant effects and results in a drug-paired environment eliciting conditioned activity. We tested whether food induces similar effects.
Le Merrer, Julie, Stephens, David N
core   +1 more source

Functional Selectivity of Allosteric Interactions within GPCR oligomers: the Dopamine D1-D3 Receptor Heterotetramer [PDF]

, 2014
The dopamine D1 receptor-D3 receptor (D1R-D3R) heteromer is being considered as a potential therapeutic target for neuropsychiatric disorders. Previous studies suggested that this heteromer could be involved in the ability of D3R agonists to potentiate ...
Antoni Cortés, Carme Lluís, Enric I. Canela, Estefania Moreno, Gemma Navarro, Hideaki Yano, Josefa Mallol, Lee, Marta Sánchez-Soto, Ning-Sheng Cai, Peter J. McCormick, Sandeep Kumar-Barodia, Sergi Ferré, Staley, Vicent Casadó, Xavier Guitart, Yamini T. Naidu   +16 more
core   +2 more sources

ChemicalTagger: A tool for semantic text-mining in chemistry. [PDF]

, 2011
BACKGROUND: The primary method for scientific communication is in the form of published scientific articles and theses which use natural language combined with domain-specific terminology. As such, they contain free owing unstructured text.
Adams, Nico, Hawizy, Lezan, Jessop, David M, Murray-Rust, Peter   +3 more
core   +3 more sources

Electrochemical oxidative radical cascade cyclization of dienes and diselenides towards the synthesis of seleno-benzazepines. [PDF]

RSC Adv
Hu L, Zhang J, Li M, Feng Y, Lu F.
europepmc   +3 more sources

Enzymatic formation of protopines by a microsomal cytochrome P-450 system of Corydalis vaginans [PDF]

, 1987
A microsomal cytochrome P-450-NADPH dependent enzyme which hydroxylates stereo- and regiospecifically carbon atom 14 of (S)- -N- methyltetrahydroprotoberberines has been discovered in a number of plant cell cultures originating from species containing ...
Rüffer, Martina, Zenk, Meinhart H.
core   +1 more source

Arylbenzazepines Are Potent Modulators for the Delayed Rectifier K+ Channel: A Potential Mechanism for Their Neuroprotective Effects [PDF]

, 2010
(±) SKF83959, like many other arylbenzazepines, elicits powerful neuroprotection in vitro and in vivo. The neuroprotective action of the compound was found to partially depend on its D1-like dopamine receptor agonistic activity. The precise mechanism for
Bernhard, Eric J., Chen, Xue-Qin, Hu, Guo-Yuan, Jin, Guo-Zhang, Neumeyer, John Leopold, Zhang, Ao, Zhang, Jing, Zhen, Xuechu   +7 more
core   +1 more source