Results 31 to 40 of about 5,260 (223)

Dopamine D1 vs D5 receptor-dependent induction of seizures in relation to DARPP-32, ERK1/2 and GluR1-AMPA signalling. [PDF]

, 2008
Recent reports have shown that the selective dopamine D(1)-like agonist SKF 83822 [which stimulates adenylate cyclase, but not phospholipase C] induces prominent behavioral seizures in mice, whereas its benzazepine congener SKF 83959 [which stimulates ...
Clementi, Mario, Croke, David T, Drago, John, Dunleavy, Mark, Fienberg, Allen A, Fisone, Gilberto, Greengard, Paul, Hakansson, Kerstin, Henshall, David C, Kinsella, Anthony, O\u27Sullivan, Gerard J, Sibley, David R, Waddington, John L   +12 more
core   +1 more source

Involvement of nucleus accumbens dopamine D1 receptors in ethanol drinking, ethanol-induced conditioned place preference, and ethanol-induced psychomotor sensitization in mice [PDF]

, 2012
Rationale: Dopamine D1 receptor (D1R) signaling has been associated to ethanol consumption and reward in laboratory animals.Objectives: Here, we hypothesize that this receptor, which is located within the nucleus accumbens (NAc) neurons, modulates ...
Bahi, Amine, Dreyer, Jean-Luc
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Unusual thermolysis of azacyclic allene under microwave conditions: crystal structure of (3RS,3aSR,8RS,8aRS)-methyl 5,6-dimethoxy-3a,10-dimethyl-1-phenyl-3,3a,8,8a-tetrahydro-3,8-(epiminomethano)cyclopenta[a]indene-2-carboxylate from synchrotron X-ray diffraction

Acta Crystallographica Section E: Crystallographic Communications, 2017
The title compound, C25H27NO4 (I), the product of the unusual thermolysis of azacyclic allene methyl 10,11-dimethoxy-3,8-dimethyl-6-phenyl-3-azabenzo[d]cyclodeca-4,6,7-triene-5-carboxylate, represents a bicyclic heterosystem and crystallizes in the ...
Le Tuan Anh, Alexander A. Titov, Maxim S. Kobzev, Leonid G. Voskressensky, Alexey V. Varlamov, Pavel V. Dorovatovskii, Victor N. Khrustalev   +6 more
doaj   +1 more source

Notch Antagonists: Potential Modulators of Cancer and Inflammatory Diseases. [PDF]

, 2016
Notch is a key player in various developmental processes during the embryonic stage as well as in regulating tissue homeostasis, cell differentiation, and stem cell maintenance in adult life.
Dela Golshayan, Lucienne Juillerat-Jeanneret, Massard C., Müllberg J., Okada H., Rajesh Kumar, Shawber C.   +6 more
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DISC1–ATF4 transcriptional repression complex: dual regulation of the cAMP-PDE4 cascade by DISC1 [PDF]

, 2013
Disrupted-In-Schizophrenia 1 (DISC1), a risk factor for major mental illnesses, has been studied extensively in the context of neurodevelopment. However, the role of DISC1 in neuronal signaling, particularly in conjunction with intracellular cascades ...
Baccarella, A., Flood, Zachary, Frank, Christopher Lee, Ishizuka, K, Park, S K, Park, Y-U, Sawa, A, Soda, Takahiro, Tsai, Li-Huei   +8 more
core   +1 more source

In vivo antinociception of potent mu opioid agonist tetrapeptide analogues and comparison with a compact opioid agonist - neurokinin 1 receptor antagonist chimera

Molecular Brain, 2012
Background An important limiting factor in the development of centrally acting pharmaceuticals is the blood-brain barrier (BBB). Transport of therapeutic peptides through this highly protective physiological barrier remains a challenge for peptide drug ...
Guillemyn Karel, Kleczkowska Patrycja, Novoa Alexandre, Vandormael Bart, Van den Eynde Isabelle, Kosson Piotr, Asim Muhammad, Schiller Peter W, Spetea Mariana, Lipkowski Andrzej W, Tourwé Dirk, Ballet Steven   +11 more
doaj   +1 more source

Activation of D1 Dopamine Receptors Induces Emergence from Isoflurane General Anesthesia [PDF]

, 2012
Background: A recent study showed that methylphenidate induces emergence from isoflurane anesthesia. Methylphenidate inhibits dopamine and norepinephrine reuptake transporters.
Brown, Emery N., Chemali, Jessica J., Solt, Ken, Taylor, Norman E.   +3 more
core   +1 more source

Targeting the vasopressin type-2 receptor for renal cell carcinoma therapy. [PDF]

, 2020
Arginine vasopressin (AVP) and its type-2 receptor (V2R) play an essential role in the regulation of salt and water homeostasis by the kidneys. V2R activation also stimulates proliferation of renal cell carcinoma (RCC) cell lines in vitro.
Calvet, James P, Dwivedi, Nidhi, Enders, Jonathan, Jamadar, Abeda, Kakade, Vijayakumar R, Neil, Maura O', Rao, Reena, Sinha, Sonali, Tao, Shixin, Thomas, Sufi M, Weiss, Robert H   +10 more
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Recent Synthetic Advances in C–H/N–H Functionalization of 1H‐Pyrazoles: Diverse Strategies Across Variously Substituted Scaffolds

The Chemical Record, Volume 25, Issue 12, December 2025.
Systematic overview of pyrazole functionalization reactions from C‐5 to N−H. It covers different strategies, from traditional cross‐coupling of prefunctionalized pyrazoles to more efficient direct functionalizations. This review briefly and systematically overviews C–H and N–H functionalization reactions of pyrazoles, aimed at creating new CC and C ...
Karolina Dzedulionytė Müldür, Asta Žukauskaitė, Algirdas Šačkus, Eglė Arbačiauskienė   +3 more
wiley   +1 more source

Synthesis and study of biological activity of tetrahydro-1H-[3]-benzazepines [PDF]

, 2017
The 3-Benzazepines are an important class of compounds in drug discovery due to their biological activity such as analgesic, antihypertensive or anticancer properties as well as dopaminergic or antidopaminergic activity. In particular, the tetrahydro-1H-[
Díaz, Amelia, Lucena-Serrano, Ana, Lucena-Serrano, Cristina, López-Romero, Juan Manuel, Valpuesta-Fernandez, Maria   +4 more
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