Results 41 to 50 of about 5,260 (223)

Interactions of a Dopamine D Receptor Agonist with Glutamate NMDA Receptor Antagonists on the Volitional Consumption of Ethanol by the mHEP Rat [PDF]

, 2013
Stimulation of the dopamine D1 receptor is reported to cause the phosphorylation of DARPP-32 at the thre34 position and activates the protein. If intracellular Ca2+ is increased, such as after activation of the glutamate NMDA receptor, calcineurin ...
Brian McMillen, Cloninger, Courtney Lommatzsch, Davis, Gonzales, Helen Williams, Kranzler, Kranzler, Lovinger, Malpass, Malpass, Michael Sayonh, Morrisett, Myers, Myers, Risinger, Siggins, Zar   +17 more
core   +2 more sources

Benzo‐fused Nitrogen Heterocycles by Asymmetric Ring Expansion and Stereochemically Retentive Re‐contraction of Cyclic Ureas

Angewandte Chemie, Volume 136, Issue 12, March 18, 2024.
Asymmetric deprotonation of N‐benzyl urea derivatives of nitrogen heterocycles leads to enantioselective insertion of the benzylic substituent into an aromatic C−N bond. Treatment of the ring‐expanded products induces a stereospecific ring‐contraction that results in an overall asymmetric enantioselective one‐carbon enlargement of the heterocycle ...
Rajendra K. Mallick, Matej Žabka, Jonathan Clayden   +2 more
wiley   +2 more sources

Multistep Reactions Initiated by Amine‐Based Organometallic Methods

European Journal of Organic Chemistry, Volume 28, Issue 40, October 29, 2025.
The advent of C–H activation and other organometallic methodologies making use of transient directing groups or free amines themselves for the elaboration of amine substrates provides unique access to cascade‐type reactions that can generate significant molecular complexity in one pot. The pursuit of atom‐ and step‐economical pathways to access complex
Victoria D. Ho, Olutayo N. Farinde, Kendra K. Shrestha, Michael C. Young   +3 more
wiley   +1 more source

Expression profiles of TRPV1, TRPV4, TLR4 and ERK1/2 in the dorsal root ganglionic neurons of a cancer-induced neuropathy rat model

, 2018
Background: The spread of tumors through neural routes is common in several types of cancer in which patients suffer from a moderate-to-severe neuropathy, neural damage and a distorted quality of life.
Elsadek, Bakheet, Maqboul, Ahmad
core   +2 more sources

Activation of Ventral Tegmental Area 5-HT2C Receptors Reduces Incentive Motivation [PDF]

, 2016
FUNDING AND DISCLOSURE The research was funded by Wellcome Trust (WT098012) to LKH; and National Institute of Health (DK056731) and the Marilyn H. Vincent Foundation to MGM.
AH Rezvani, AJ Hill, B Doslikova, C Harvey-Lewis, C Miguelez, CD Wynne, Christopher M Bradshaw, CK Martin, CM Bradshaw, CM Olarte-Sanchez, CM Olarte-Sanchez, CM Olarte-Sanchez, Cristian M Olarte-Sánchez, David J Lyons, DD Lam, DJ Hayes, DJ Urban, ED Levin, G Bezzina, G Paxinos, GA Higgins, GM Alexander, GS Kranz, HY Meltzer, JC Halford, JD Salamone, JE Aberman, JE Blundell, L Valencia-Torres, LK Burke, LK Burke, LK Burke, LK Heisler, Lora K Heisler, Lourdes Valencia-Torres, M Filip, Martin G Myers, Megan Greenwald-Yarnell, MJ Bubar, MJ Bubar, NR Richardson, P Skjoldager, PJ Fletcher, PJ Fletcher, PR Killeen, PR Killeen, RJ DiLeone, S Burbassi, S Higgs, SM Graves, SP Vickers, Teodora Georgescu, V Di Matteo, W Hodos, WJ Thomsen, Y Xu   +55 more
core   +1 more source

Advances in Ligand‐Driven Pd‐Catalyzed C─H Functionalizations: Recent Insights and Updates

ChemCatChem, Volume 17, Issue 15, August 7, 2025.
The most significant advances in ligand‐driven Pd‐catalyzed organic synthesis over the past two years are presented. Processes involving C─H activation of substrates, avoiding their prefunctionalization are illustrated. Both the activity and selectivity of the catalyst depend on the design of the ligands (pyridones, pyridines, amino acids, phosphines ...
Jesús Moradell, Cosmina Bohan, Alexandra Pop, Esteban P. Urriolabeitia   +3 more
wiley   +1 more source

Comparative study of dopaminergic activity of tetrahydro-1H-[3]-benzazepines and their precursors [PDF]

, 2016
The discovery of the tetrahydro-1H-[3]-benzazepine SCH23390 [1], represented one of the most important advances in the study of dopaminergic receptors due to their behavior as a selective D1 receptor antagonist.
Contreras-Cáceres, Rafael, Díaz, Amelia, Lucena-Serrano, Cristina, López-Romero, Juan Manuel, Rivera-Ramirez, Alicia, Valpuesta-Fernandez, Maria   +5 more
core  

Synthesis and Transformations of Bioactive Scaffolds via Modified Mannich and aza‐Friedel–Crafts Reactions

The Chemical Record, Volume 25, Issue 8, August 2025.
The stabilization of precursors substituted with 2‐, 1‐naphthol via partially aromatic ortho‐quinone methide intermediate was tested with different cyclic imines in [4+2] cycloaddition.8‐Hydroxyquinoline as a formal 1‐naphthol analogue in Mannich reaction was tested.The formed Mannich bases substituted with 2‐ and 1‐naphthol, 5‐chloro‐8 ...
Dóra Hegedűs, Nikoletta Szemerédi, Gabriella Spengler, István Szatmári   +3 more
wiley   +1 more source

Convenient Synthesis of 2-Benzazepines via Radical Cyclization [PDF]

The Journal of Organic Chemistry, 2003
AbstractFor Abstract see ChemInform Abstract in Full Text.
Akio, Kamimura, Yohei, Taguchi, Yoji, Omata, Masahiko, Hagihara   +3 more
openaire   +2 more sources

Sex differences in the vasoactive effect of transient receptor potential channels: TRPM3 as a new therapeutic target for (neuro)vascular disorders

British Journal of Pharmacology, Volume 182, Issue 11, Page 2503-2523, June 2025.
Abstract Background and Purpose Sex‐dependent vascular effects of transient receptor potential (TRP) channels and sex dimorphism in migraine are not yet fully characterized. We investigated the differential vasoactive effects of TRP ankyrin 1 (TRPA1), TRP melastatin 3 (TRPM3) and TRP vanilloid 1 (TRPV1) channels, their pharmacological mechanism(s), and
Eduardo Rivera‐Mancilla, Usha M. Musterd‐Bhaggoe, Dennis Schutter, Antoon van den Bogaerdt, Arnaud J. P. E. Vincent, Carlos M. Villalón, Alexander H. J. Danser, Antoinette MaassenVanDenBrink   +7 more
wiley   +1 more source