Results 51 to 60 of about 5,260 (223)

Recent Total Syntheses of Cephalotaxine‐Type Alkaloids and Their Structural Diversification (2021–2024): An Update

Asian Journal of Organic Chemistry, Volume 14, Issue 3, March 2025.
This review presents an analysis of ten recent total syntheses of cephalotaxine‐type alkaloids published between 2021 and 2024. The structural diversification strategies developed during this period are described. Additionally, a new structural classification system for this alkaloid class is proposed.
Yeju Oh, Anagha Reneesh, Hongjun Jeon
wiley   +1 more source

Stereocontrolled addition of Grignard reagents to oxa-bridged benzazepines: highly efficient synthesis of functionalized benzazepine scaffolds

RSC Advances, 2020
An efficient and highly diastereoselective synthesis of 2-substituted benzo[b]azepin-5-olviastereocontrolled addition of Grignard reagents to oxa-bridged benzazepines has been developed.
Yuewei Zhang, Qingqing Bao, Ning Zhang, Shuohang Wang, Xue Yu   +4 more
openaire   +3 more sources

Palladium-Catalyzed Carbonylative Cyclization of Amines via γ-C(sp3)-H Activation: Late-Stage Diversification of Amino Acids and Peptides [PDF]

, 2016
This document is the Accepted Manuscript version of a Published Work that appeared in final form in ACS Catalysis, copyright © American Chemical Society after peer review and technical editing by the publisher.
Alonso, Inés, Carretero, Juan C., Gómez Arrayás, Ramón, Hernando, Elier, Martínez, Ángel Manu, Rodríguez, Nuria, Villalva, Julia   +6 more
core   +2 more sources

Phenol (bio)isosteres in drug design and development

Archiv der Pharmazie, Volume 358, Issue 1, January 2025.
This review explores the pivotal role of phenol bioisosteres in drug design, highlighting their potential to overcome the limitations of phenolic compounds, such as poor bioavailability and rapid metabolism. By examining diverse bioisosteric replacements, from benzimidazolones to quinolinones, it is demonstrated how these modifications enhance drug ...
Calvin Dunker, Katja Schlegel, Anna Junker   +2 more
wiley   +1 more source

Role of movement in long-term basal ganglia changes: implications for abnormal motor responses [PDF]

, 2013
Abnormal involuntary movements (AIMs) and dyskinesias elicited by drugs that stimulate dopamine receptors in the basal ganglia are a major issue in the management of Parkinson’s disease (PD).
FRAU, LUCIA, FRAZZITTA G, MORELLI, MICAELA, SIMOLA, NICOLA   +3 more
core   +1 more source

Optimized psilocybin production in tryptophan catabolism‐repressed fungi

Microbial Biotechnology, Volume 17, Issue 11, November 2024.
Here, we developed an in vivo psilocybin production chassis, based on repression of l‐tryptophan catabolism. By genome mining, we identified two aminotransferase ARO8/9 orthologs in Aspergillus nidulans involved in l‐tryptophan catabolism. Double deletion of the aminotransferase genes aroH1 and aroH2 resulted in a 10‐fold increased psilocybin ...
Slavica Janevska, Sophie Weiser, Ying Huang, Jun Lin, Sandra Hoefgen, Katarina Jojić, Amelia E. Barber, Tim Schäfer, Janis Fricke, Dirk Hoffmeister, Lars Regestein, Vito Valiante, Johann E. Kufs   +12 more
wiley   +1 more source

Neuroblastoma and its Target Therapies: A Medicinal Chemistry Review

ChemMedChem, Volume 19, Issue 9, May 2, 2024.
Searching for a cure for neuroblastoma: This review highlights the urgent need to find a cure for high‐risk neuroblastoma. It provides an overview of the current treatment available and the drug discovery approach of seven drugs that reached clinical trial.
A. Gerges, U. Canning
wiley   +1 more source

Integrated Ugi-Based Assembly of Functionally, Skeletally, and Stereochemically Diverse 1,4-Benzodiazepin-2-ones [PDF]

, 2015
A practical, integrated and versatile U-4CR-based assembly of 1,4-benzodiazepin-2-ones exhibiting functionally, skeletally, and stereochemically diverse substitution patterns is described.
Abdelaziz El Maatougui, Armando Navarro-Vázquez, Armstrong R. W., Atkins R. J., Azuaje A., Baerends E. J., Bateson A. N., Belvisi L., Bolli M. H., Carlier P. R., Carlier P. R., Christian F. Masaguer, Cuny G., De Clerq E., De Silva R. A., Donald J. R., Dourlat J., Dömling A., Eddy Sotelo, Eichkorn K., Ettari R., Evans B. E., Gilman N. G., Gordon C. P., Guggenhem K. G., He P., Horton D. A., Hsu D. C., Huang Y., Jensen F., Jhonny Azuaje, José Carlos González-Gomez, José M. Pérez-Rubio, Keating T. A., Kleemann A., Kutzelnigg W., Lam P. C. H., Lecinska P., Linscheid P., Lodewyk M. W., Marcaccini S., Marcaccini S., Marta Teijeira, Micale N., Neese F., Petrovich A. G., Sañudo M., Schaefer A., Shaabani A., Shaabani A., Sinnecker S., Smith S. G., Smith S. G., Tempest P., Vicente Yaziji, Vı́ctor M. Sánchez-Pedregal, Weigend F., Xu J., Yang S. K., Zhang Y., Zhu J.   +60 more
core   +6 more sources

Review on allosteric modulators of dopamine receptors so far

Health Science Reports, Volume 7, Issue 3, March 2024.
Abstract Background Contemporary research is predominantly directed towards allosteric modulators, a class of compounds designed to interact with specific sites distinct from the orthosteric site on G protein‐coupled receptors. These allosteric modulators play a pivotal role in influencing diverse pharmacological effects, such as agonism/inverse ...
Fentaw Girmaw
wiley   +1 more source

Conditioning to injection procedures and repeated testing increase SCH 23390-induced catalepsy in mice [PDF]

, 1999
The cataleptic behavior induced by the dopamine D-1 antagonist SCH 23390 (SCH) has proven to be a useful assay for investigating the sensitivity of D-1-like dopamine receptor-mediated effects during chronic drug administration. A fundamental flaw in most
Chinen, Cibele Cristina, Frussa Filho, Roberto   +1 more
core   +1 more source