Neuroblastoma and its Target Therapies: A Medicinal Chemistry Review
ChemMedChem, Volume 19, Issue 9, May 2, 2024.Searching for a cure for neuroblastoma: This review highlights the urgent need to find a cure for high‐risk neuroblastoma. It provides an overview of the current treatment available and the drug discovery approach of seven drugs that reached clinical trial.
A. Gerges, U. Canning
wiley +1 more source
Novas metodologias sintéticas utilizando reator de micro-ondas fundamentadas nos princípios da química verde (azidas alílicas e reações de cicloadição) [PDF]
, 2010 TCC (graduação) - Universidade Federal de Santa Catarina, Centro de Ciências Físicas e Matemáticas, Curso de Química.Este trabalho objetiva a preparação de compostos nitrogenados multifuncionais e de sistemas alílicos contendo o grupo azido, os quais são
Monteiro, Gustavo Claro
core
New Catalytic Routes to Benzofused Seven-Membered Azaheterocycles [PDF]
, 2021 Benzazepines, benzodiazepines and benzoxazepines compose a privileged family of natural products and pharmaceuticals. Their remarkable biological activity made them useful drugs to treat a large variety of issues.
Velasco Rubio, Álvaro
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ChemBioChem, Volume 25, Issue 2, January 15, 2024.We herein report the identification of UR‐NR435 (25), a SCH‐23390‐based fluorescent ligand bearing a 5‐TAMRA dye, as suitable for fluorescence microscopy at the D1R. Single‐digit nanomolar binding affinity could be determined in radioligand competition binding and molecular brightness studies at D1‐like receptors.
Niklas Rosier +11 more
wiley +1 more source
A suitable preparation of N-sulfonyl-1,2,3,4-tetrahydroisoquinolines and their ring homologs with a reusable Preyssler heteropolyacid as catalyst [PDF]
, 2010 The preparation of N-sulfonyl-1,2,3,4-tetrahydroisoquinolines, N-sulfonyl-2,3,4,5-tetrahydro-1H-2-benzazepines and N-sulfonyl-1,2,3,4,5,6-hexahydrobenzazocine was catalyzed by a Preyssler heteropolyacid, H₁₄[NaP₅W₃₀O₁₁₀], (PA), supported on silica ...
Autino, Juan Carlos +3 more
core +1 more source
ClassyFire: automated chemical classification with a comprehensive, computable taxonomy [PDF]
, 2016 Additional file 5. Use cases. Text-based search on the ClassyFire web server. (A) Building the query.
Christoph Steinbeck +11 more
core +5 more sources
, 2014 Insecticide resistance amongst disease vectors is a growing problem and novel compounds are needed. Biogenic amines are important for neurotransmission and we have recently shown a potential role for these in mosquito fertility.
Crisanti, A +3 more
core +2 more sources
A novel, tandem construction of C-N and C-C bonds: facile and one-pot transformation of the Baylis-Hillman adducts into 2-benzazepines [PDF]
, 2004 A novel reaction involving tandem construction of C-N and C- C bonds via the simultaneous Ritter and Houben-Hoesch reactions on Baylis-Hillman adducts leading to a convenient, one-pot synthesis of 2-benzazepine derivatives is described.
Basavaiah, Deevi +1 more
core +1 more source
Rh(III)‐Catalyzed [5+1] Oxidative Cycloaddition of Arylguanidines with Alkynes: A Novel Access to C4‐Disubstituted 1,4‐ Dihydroquinazolin‐2‐amines [PDF]
, 2015 NOTICE: This is the peer reviewed version of the following article: Cajaraville, A., Suárez, J., López, S., Varela. J. A., Saá, C. (2015). Rh(III)‐Catalyzed [5+1] Oxidative Cycloaddition of Arylguanidines with Alkynes: A Novel Access to C4‐Disubstituted ...
Cajaraville Leiro, Ana +4 more
core +1 more source
Seven-membered Rings Through Metal-free Rearrangement Mediated By Hypervalent Iodine. [PDF]
, 2015 A versatile and metal-free approach for the synthesis of carbocycles and of heterocycles bearing seven- and eight-membered rings is described. The strategy is based on ring expansion of 1-vinylcycloalkanols (or the corresponding silyl or methyl ether ...
de Carvalho, João Ernesto +4 more
core +3 more sources