Results 91 to 100 of about 11,715 (300)

WTAP‐Mediated m6A Modification Targets the LRP1‐Lipid Metabolism Axis to Regulate Joint Cartilage Regeneration

open access: yesAdvanced Science, EarlyView.
WTAP drives cartilage regeneration by activating an LRP1‐dependent lipid metabolic program in macrophages, enhancing IL‐10 and TGF‐β secretion to promote chondrogenic differentiation. Leveraging this mechanism, virtual screening identifies LRP1‐targeting compounds that effectively stimulate cartilage repair, highlighting a druggable epigenetic ...
Chenyan Huang   +6 more
wiley   +1 more source

Cascade metathesis reactions for the synthesis of taxane and isotaxane derivatives [PDF]

open access: yes, 2016
Tricyclic isotaxane and taxane derivatives and have been synthesized by a very efficient cascade ring-closing dienyne metathesis (RCDEYM) reaction, which formed the A and B rings in one operation.
Aouzal, Remi   +7 more
core   +3 more sources

A novel mouse model of endometriosis: Simulating the recurrent hemorrhagic microenvironment of clinical lesions

open access: yesAnimal Models and Experimental Medicine, EarlyView.
To address the limitations of existing models, this study innovatively established a mouse model of endometriosis (EMs) capable of mimicking cyclic bleeding. Our results confirmed that this model recapitulates the complete pathological progression from ectopic lesion establishment to systemic responses, exhibiting superior clinical relevance compared ...
Yu Zhuang   +7 more
wiley   +1 more source

Effect of catalytic conditions on the synthesis of new aconitate esters [PDF]

open access: yes, 2011
Sugar cane is a crop which generates large amounts of biomass and a juice rich in highvalue natural molecules. After extracting sugar from the juice, the recovering of various compounds such as organic acids contained in molasses could contribute to ...
Hoareau, William   +4 more
core   +3 more sources

Mimikry eines Lichtsammelkomplexes zur Beschleunigung der Photooxidation in asymmetrischen Lipidmembran‐Nanoreaktoren

open access: yesAngewandte Chemie, EarlyView.
Biomimetische Liposomen‐Nanoreaktoren, die natürliche Lichtsammelkomplexe nachahmen, ermöglichen eine effiziente Photooxidation von NADH. Membrangebundenes Fluorescein überträgt Energie über FRET an membrangebundenes Eosin Y und oxidiert so NADH.
Julian Bösking   +13 more
wiley   +1 more source

Exploring the Phytochemical Landscape of the Early-Diverging Flowering Plant Amborella trichopoda Baill. [PDF]

open access: yes, 2019
Although the evolutionary significance of the early-diverging flowering plant Amborella (Amborella trichopoda Baill.) is widely recognized, its metabolic landscape, particularly specialized metabolites, is currently underexplored.
Chang, Lijing   +3 more
core   +1 more source

Analysis of gas chromatography/mass spectrometry data for catalytic lignin depolymerization using positive matrix factorization [PDF]

open access: yes, 2018
Various catalytic technologies are being developed to efficiently convert lignin into renewable chemicals. However, due to its complexity, catalytic lignin depolymerization often generates a wide and complex distribution of product compounds.
Barrett, JA   +7 more
core   +1 more source

Mimicking a Light‐Harvesting Complex to Accelerate Photooxidation in Asymmetric Lipid Membrane Nanoreactors

open access: yesAngewandte Chemie International Edition, EarlyView.
Biomimetic liposome nanoreactors mimicking natural light‐harvesting complexes enable efficient photooxidation of NADH. Membrane‐anchored fluorescein transfers energy via FRET to membrane anchored eosin Y, oxidizing NADH. While symmetric membranes show little improvement, asymmetric chromophore distribution enhances photooxidation rates by up to 27 ...
Julian Bösking   +13 more
wiley   +1 more source

Mass spectrometric analysis of epimeric 3α/3β functionalized steroids. [PDF]

open access: yes, 2007
Tandem mass spectrometry (MS/MS) using an atmospheric pressure chemical ionization (APCI) source in positive mode (+) reveals different intensity ratios of two fragment peaks of the epimeric cholestane derivatives synthesized from 3{460}- or 3β ...
Almeida, Paulo   +5 more
core   +1 more source

Preparation of 4 '-spirocyclobutyl nucleoside analogues as novel and versatile adenosine scaffolds

open access: yes, 2019
Despite the large variety of modified nucleosides that have been reported, the preparation of constrained 4 '-spirocyclic adenosine analogues has received very little attention.
De Vleeschouwer, Freija   +10 more
core   +1 more source

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