Electrostatic Contributions of Aromatic Residues in the Local Anesthetic Receptor of Voltage-Gated Sodium Channels [PDF]
, 2008 Antiarrhythmics, anticonvulsants, and local anesthetics target voltage-gated sodium channels, decreasing excitability of nerve and muscle cells. Channel inhibition by members of this family of cationic, hydrophobic drugs relies on the presence of highly ...
Ahern, Christopher A. +3 more
core +2 more sources
Aptamer-based cocaine assay using a nanohybrid composed of ZnS/Ag2Se quantum dots, graphene oxide and gold nanoparticles as a fluorescent probe [PDF]
, 2020 Authors report on a new fluoro-graphene-plasmonic nanohybrid aptamer-based fluorescent nanoprobe for cocaine. To construct the nanoprobe, newly synthesized glutathione-capped ZnS/Ag 2Se quantum dots (QDs) were first conjugated to graphene oxide (GO) to ...
Abdolvand, Amin +4 more
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Topical analgesia for acute otitis media [PDF]
, 2006 BACKGROUND: Acute otitis media (AOM) is a spontaneously remitting disease for which pain is the most distressing symptom. Antibiotics are now known to have less benefit than previously assumed.OBJECTIVES: To assess the effectiveness of topical analgesia ...
Del Mar, C +4 more
core +1 more source
New patents on topical anesthetics. [PDF]
, 2014 Anesthesia is defined as a total or partial loss of sensation and it may be general, local or topical, depending on the method of drug administration and area of the body affected.
CALVIERI, Stefano +6 more
core +1 more source
Frontiers in Pharmacology, 2021 We have developed an automated patch-clamp protocol that allows high information content screening of sodium channel inhibitor compounds. We have observed that individual compounds had their specific signature patterns of inhibition, which were ...
Krisztina Pesti +10 more
doaj +1 more source
Comparing the Effects of Najo-Caine P® and Topical Benzocaine on Reducing the Pain of Needle Insertion in Palatal Anesthesia in 9-12 Year Old Children: A Randomized Clinical Trial [PDF]
Journal of Mazandaran University of Medical Sciences, 2023 Background and purpose: Pain management is one of the important issues in dental treatments. Fear of pain can make the process of anesthesia injection before dental treatment difficult for both the dentist and the patient.
Mehdi Taghian +3 more
doaj
First Report of Nephrocalcinosis in Aquacultured Brazilian Sardine (Sardinella brasiliensis Steindachner, 1879). [PDF]
J Fish DisABSTRACT While nephrocalcinosis (kidney stones) is uncommon in wild teleost fish, various environmental and nutritional factors could lead to its occurrence in aquacultured fish. This study presents the first documented case of kidney stones in aquacultured Brazilian sardine (Sardinella brasiliensis). During necropsy, eighteen hard, white kidney stones
Vieira DS +5 more
europepmc +2 more sources
Applied Sciences, 2023 Compounding formulations, including semi-solid medication forms, must meet criteria related to specific stability and quality, during a period of their use.
Lucyna Bułaś +3 more
doaj +1 more source
Contact allergy to local anaesthetics–value of patch testing with a caine mix in the baseline series [PDF]
, 2012 BACKGROUND: Contact allergy to local anaesthetics is relatively common. Patch testing with benzocaine in the European baseline series is recommended for diagnosis, even though a caine mix has been previously suggested to be superior.
Brinca, A +2 more
core +1 more source
Molecules, 2022 Agarose (AG) is a naturally occurring biocompatible marine seaweed extract that is converted to hydrocolloid gel in hot water with notable gel strength. Currently, its mucoadhesion properties have not been fully explored.
Muhammad Ali Syed +15 more
doaj +1 more source