Results 171 to 180 of about 30,052 (209)

Benzofuran based PDE4 inhibitors

Bioorganic & Medicinal Chemistry, 1999
Replacement of the 3,4-dialkoxyphenyl substructure common to a number of PDE4 inhibitors with a 2-alkyl-7-methoxybenzofuran unit is described. This substitution can result in either enhancement or substantial reductions in PDE4 inhibitory activity depending on the system to which it is applied.
D G, McGarry, J R, Regan, F A, Volz, C, Hulme, K J, Moriarty, S W, Djuric, J E, Souness, B E, Miller, J J, Travis, D M, Sweeney   +9 more
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Benzofurans, benzofuran dimers and other constituents from Ophryosporus charua

Phytochemistry, 1997
Aerial parts of Ophryosporus charua afforded several known and five new benzofuran derivatives, as well as two prenylated p-hydroxyacetophenone derivatives. The essential oil contained lavandulyl acetate, lavandulol and dehydrotremetone as the main constituents.
Marina E.P. de Lampasona, César A.N. Catalán, Thomas E. Gedris, Werner Herz   +3 more
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ChemInform Abstract: RESEARCH IN BENZOFURAN SERIES. LIX. BENZOFURAN AMIDINES

Chemischer Informationsdienst, 1976
AbstractEine große Anzahl von Benzofuran‐Amidin‐Derivaten vom Typ (I)‐(VI) wird nach klassischen Methoden synthetisiert und als Salze (Hydrochloride, Dihydrochloride, Sesquioxalate) isoliert.
ALEX ARESCHKA, JEAN MAHAUX, FRANCIS VERBRUGGEN, CHRISTIAN HOUBEN, MARCEL DESCAMPS, JOSEPH BEERSAERTS, MICHEL COLOT, JEAN‐PIERRE HEYNDRICK, MARCEL VAN DAMME, ROBERT CHARLIER   +9 more
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Benzofuran bioisosteres of hallucinogenic tryptamines

Journal of Medicinal Chemistry, 1992
The benzofuran analogues of the hallucinogens 5-methoxy-N,N-dimethyltryptamine and 5-methoxy-alpha-methyltryptamine were synthesized and evaluated for affinity at the serotonin 5-HT2 and 5-HT1A receptors in rat brain homogenate, labeled with [125I]-1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane ([125I]DOI) and [3H]-8-hydroxy-2-(N,N-di-n-propylamino ...
Z, Tomaszewski, M P, Johnson, X, Huang, D E, Nichols   +3 more
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Benzofuran Trimers for Organic Electroluminescence

Chemistry – A European Journal, 2004
AbstractFour linear benzofuran trimers have been prepared by a two‐stage synthetic procedure. They were tested as materials for organic electroluminescence (OEL). Precursor phenylene ethynylene oligomers were formed in the first stage, then after removal of the phenolic hydroxyl protecting groups, a base was used to promote the cyclization of ortho ...
Sally, Anderson, Peter N, Taylor, Geraldine L B, Verschoor   +2 more
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Antiviral benzofurans from Eupatorium chinense

Phytochemistry, 2016
Eleven benzofuran dimers, (+)-dieupachinins A-E, (-)-dieupachinins A-E and dieupachinin F, a benzofuran trimer trieupachinin A, as well as seven known compounds were isolated from the roots of Eupatorium chinense. The enantiomers of racemates dieupachinins A-E were separated by chiral HPLC. The structures with absolute configurations were elucidated on
Wen-Jing, Wang, Lei, Wang, Zhong, Liu, Ren-Wang, Jiang, Zhi-Wen, Liu, Man-Mei, Li, Qing-Wen, Zhang, Yi, Dai, Yao-Lan, Li, Xiao-Qi, Zhang, Wen-Cai, Ye   +10 more
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Bioactive Benzofuran derivatives: A review

European Journal of Medicinal Chemistry, 2015
In nature's collection of biologically active heterocycles, benzofuran derivatives constitute a major group. The broad spectrum of pharmacological activity in individual benzofurans indicates that this series of compounds is of an undoubted interest.
Hena, Khanam, , Shamsuzzaman
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Benzofuran derivatives: a patent review

Expert Opinion on Therapeutic Patents, 2013
Benzofuran moiety constitutes the core of several interesting pharmacologically active natural products. Benzofurans are among feasible potent active inhibitors against many diseases, viruses, microbes, fungus and enzymes. Several series of therapeutically important synthetic and naturally occurring benzofuran-containing compounds are reported in this ...
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Ionic hydrogenation of benzofurans

Chemistry of Heterocyclic Compounds, 1975
Benzofurans are arranged in the order 2-methylbenzofuran > 3-methylbenzofuran > benzofuran with respect to the case with which they undergo ionic hydrogenation. Benzofuran and 2-methylbenzofuran are protonated in the 3 position of the heterocyclic ring, whereas 3-methylbenzofuran is protonated in the 2 position.
�. A. Karakhanov, E. A. Dem'yanova, E. G. Shkarin, E. A. Viktorova   +3 more
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