Results 41 to 50 of about 472 (93)

Design, synthesis and evaluation of anticancer activity of novel 2-thioxoimidazolidin-4-one derivatives bearing pyrazole, triazole and benzoxazole moieties

Chemistry Central Journal, 2018
A novel series of substituted 2-thiohydantoin incorporated with benzoimidazole, pyrazole, triazole and/or benzoxazole moieties has been synthesized using (E)-3-[1-(4-bromophenyl)ethylideneamino]-2-thioxoimidazolidin-4-one 1 as the key starting material ...
Heba A. Elhady, Refat El-Sayed, Hamedah S. Al-nathali   +2 more
doaj   +1 more source

Docking and Molecular Dynamics Simulation‐Based Analysis of Advanced Small‐Molecule Kinase Inhibitors Identified pre‐let‐7 miRNA Binders

ChemBioChem, Volume 26, Issue 22, November 17, 2025.
An integrated computational approach evaluating the binding between pre‐let‐7 microRNA and small‐molecule kinase inhibitors (SMKIs) revealed varied pre‐let‐7 binding affinities among the advanced SMKIs. The results justified the characterization of potential RNA targets for kinase inhibitors and small molecules with protein targets in general.
Soma Roy, Yang Liu, Peng Wu
wiley   +1 more source

Illuminating Tau Aggregates: Multiscale Approaches for Detection, Imaging, and Understanding

Aggregate, Volume 6, Issue 10, October 2025.
This review presents recent advances in molecular imaging of tauopathies, focusing on tau aggregation mechanisms, structural polymorphism, and imaging strategies. It highlights the development of tau‐selective fluorescent probes and PET tracers and explores emerging techniques such as cryo‐EM and super‐resolution imaging, offering a multiscale ...
Kaustubh R. Bhuskute, Jiayi Fan, Amandeep Kaur   +2 more
wiley   +1 more source

Advances in organic thermoelectric materials: From molecular design to device implementation

Information &Functional Materials, Volume 2, Issue 2, Page 105-117, June 2025.
Organic thermoelectric materials provide a lightweight and flexible platform for the harvesting of low‐grade heat. This review focuses on advances in p‐ and n‐type materials, doping strategies, and scalable device fabrication. Abstract Organic thermoelectric materials have emerged as compelling candidates for harvesting low‐grade heat in flexible and ...
Qingshuo Wei, Shohei Horike
wiley   +1 more source

Advances and Outlooks for Carbon Nanotube‐Based Thermoelectric Materials and Devices

Advanced Materials, Volume 37, Issue 13, April 2, 2025.
The unique structure of carbon nanotubes (CNTs) offers excellent electrical, mechanical properties, and surface area, enhancing their use in flexible thermoelectric materials. This review highlights recent advances in CNT‐based thermoelectrics, focusing on doping, composites, stability improvement, and applications in wearable devices, while addressing
Shanshan Zhou, Xiao‐Lei Shi, Lan Li, Qian Liu, Boxuan Hu, Wenyi Chen, Chenyang Zhang, Qingfeng Liu, Zhi‐Gang Chen   +8 more
wiley   +1 more source

Conjugative Effect: A Strategical Modulation of Molecular n‐Dopants for Organic Semiconductors

FlexTech, Volume 1, Issue 1, Page 6-16, March 2025.
Conjugative effect in organic n‐doping. ABSTRACT An efficient n‐dopant is essential to narrow the metal‐organic energy barriers for efficient organic semiconductor optoelectronic devices. Molecular n‐dopants feature clear merits of versatile molecular manipulation.
Yang Lu, Minqiang Mai, Xuewen Wang, Dongdong Zhang   +3 more
wiley   +1 more source

Synthesis, Characterization, and Physicochemical Studies of Mixed Ligand Complexes of Inner Transition Metals with Lansoprazole and Cytosine

Journal of Chemistry, 2013
Few complexes of inner transition metals [Th(IV), Ce(IV), Nd(III), Gd(III)] have been synthesized by reacting their metal salts with lansoprazole, 2-([3-methyl-4-(2,2,2-trifluoroethoxy)pyridin-2-yl]methylsulfinyl)-1H-benzoimidazole and cytosine. All the
Sarika Verma, Sarita Shrivastva, Rashmi Shrivastva   +2 more
doaj   +1 more source

α‐Triazolylboronic Acids: A Novel Scaffold to Target FLT3 in AML

ChemMedChem, Volume 20, Issue 1, January 2, 2025.
Boronic acids represent an intriguing and unexplored class of compounds in the context of acute myeloid leukemia (AML), and they are only scantly reported as inhibitors of protein kinases. The screening of an in‐house library of boronic compounds identified α‐triazolylboronic acids as a novel chemotype for targeting FLT3 in AML. Selected compounds show
Maria Luisa Introvigne, Lorenza Destro, Luca Mologni, Valentina Crippa, Paolo Zardi, Francesco Fini, Fabio Prati, Emilia Caselli, Alfonso Zambon   +8 more
wiley   +1 more source

Deciphering Design of Aggregation‐Induced Emission Materials by Data Interpretation

Advanced Science, Volume 12, Issue 3, January 20, 2025.
Employing data science to elucidate the relationship between structure and properties of AIE materials in a comprehensible manner. Abstract This work presents a novel methodology for elucidating the characteristics of aggregation‐induced emission (AIE) systems through the application of data science techniques.
Junyi Gong, Ziwei Deng, Huilin Xie, Zijie Qiu, Zheng Zhao, Ben Zhong Tang   +5 more
wiley   +1 more source

Tuning The Intracellular Distribution of [3+2+1] Iridium(III) Complexes In Bacterial And Mammalian Cells By iClick Reaction With Biomolecular Carriers Functionalized With Alkynone Groups

Chemistry – A European Journal, Volume 30, Issue 56, October 8, 2024.
“The colour and intracellular distribution of iridium(III) complexes is tuned by iClick conjugation of different biomolecular carriers”. The iClick (inorganic click) reaction enables a modular modification of iridium(III) complexes with ancillary triazolato ligands carrying biological targeting groups like biotin and cholic acid.
Victoria V. L. Müller, Dominik Moreth, Konrad Kowalski, Aleksandra Kowalczyk, Magdalena Gapińska, Roger Jan Kutta, Patrick Nuernberger, Ulrich Schatzschneider   +7 more
wiley   +1 more source