Results 151 to 160 of about 625 (182)
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Inhibition of Reverse Transcriptase Activity by Benzophenanthridine Alkaloids
Journal of Natural Products, 1979Benzophenanthridine alkaloids, fagaronine 4, O-methylfagaronine 5, nitidine 1, allonitidine 3 and methoxydihydronitidine 2 have been shown to posses inhibitory activity against reverse transcriptase of RNA tumor viruses. The enzyme inhibition (50%) by these alkaloids was found in the range of 6-60 microgram per milliliter of the reaction mixture when ...
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Journal of Pharmaceutical and Biomedical Analysis, 2016
Selected benzo[c]phenathridine alkaloids were biotransformed using rat liver microsomes and identified by liquid chromatography and mass spectrometry. While the metabolites of commercially available sanguinarine and chelerythrine have been studied in detail, data about the metabolism of the minor alkaloids remained unknown.
Roman, Sandor +8 more
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Selected benzo[c]phenathridine alkaloids were biotransformed using rat liver microsomes and identified by liquid chromatography and mass spectrometry. While the metabolites of commercially available sanguinarine and chelerythrine have been studied in detail, data about the metabolism of the minor alkaloids remained unknown.
Roman, Sandor +8 more
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A New Benzophenanthridine Alkaloid from Zanthoxylum nitidum
Chinese Journal of Natural Medicines, 2009Abstract Aim To study the chemical constituents of the roots and stems of Zanthoxylum nitidum (Roxb.) DC.. Methods Silica gel and Sephadex LH-20 column chromatography were used to isolate and purify the constituents. Various spectroscopic analyses were involved to elucidate the structures.
Di GENG +4 more
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Reduction of quaternary benzophenanthridine alkaloids by NADH and NADPH
Collection of Czechoslovak Chemical Communications, 1986Spectroscopic techniques have shown that quaternary benzophenanthridine alkaloids (sanguinarine (Ia), chelerythrine (Ie), sanguilutine (If), sanguirubine (Ic), chelirubine (Ib), and chelilutine (Id)) are reduced by NADH or NADPH to their dihydro forms. The formation of the oxidized form of a coenzyme was demonstrated by HPLC.
Jan Kovář +3 more
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Sequence‐selective, pH‐dependent binding to DNA of benzophenanthridine alkaloids
Journal of Molecular Recognition, 1990AbstractThe sequence selectivity associated with binding to DNA of three alkaloids belonging to the benzophenanthridine family has been analysed by DNase I footprinting, and the results were compared with those obtained from an analysis of the behaviour of the standard intercalator, ethidium bromide.
N P, Bajaj +3 more
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Inhibition of liver alanine aminotransferase activity by some benzophenanthridine alkaloids
Journal of Medicinal Chemistry, 1981The quaternary benzophenanthridine alkaloids sanguinarine (1) and chelerythrine (2) inhibit rat liver L-alanine-:2-oxoglutarate aminotransferase (EC 2.6.1.2) activity. Nitidine (3) has no inhibitory effect. The inhibitory activity of alkaloids depends on the reactivity of the iminium bond with the nucleophilic reagent, e.g., the thiol group.
D, Walterová +5 more
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Micelle assisted structural conversion with fluorescence modulation of benzophenanthridine alkaloids
Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 2017In this study we have reported the anionic surfactant (Sodium dodecyl sulfate, SDS) driven structural conversion of two benzophenanthridine plant alkaloids namely Chelerythrine (herein after CHL) and Sanguinarine (herein after SANG). Both the alkaloids exist in two forms: the charged iminium and the neutral alkanolamine form. The iminium form is stable
Ankur Bikash, Pradhan +4 more
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Benzophenanthridine Alkaloids from Callus Cultures of Toddalia Asiatica
International Journal of Pharmaceutical Sciences and Nanotechnology, 2015Benzophenenathridine alkaloids nitidine and chelerythrine production from callus cultures of Toddalia asiatica was investigated. Callus cultures were initiated on Murashige and Skoogs medium fortified with different hormonal combinations. Nitidine and chelerythrine levels in callus culture extracts was analyzed by high performance liquid chromatography
Ciddi Veeresham, Praveena Chinthala
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Fitoterapia
Bocconia arborea S. Watson (Papaveraceae) is an abundant medicinal plant in the North of Morelos State, Mexico, which is used for the treatment of several diseases. The aim of current investigation was to isolate the compounds responsible of the relaxant effect shown by the active extracts.
Emmanuel, Gaona-Tovar +6 more
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Bocconia arborea S. Watson (Papaveraceae) is an abundant medicinal plant in the North of Morelos State, Mexico, which is used for the treatment of several diseases. The aim of current investigation was to isolate the compounds responsible of the relaxant effect shown by the active extracts.
Emmanuel, Gaona-Tovar +6 more
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Synthesis of fagaronine. Anticancer benzophenanthridine alkaloid
The Journal of Organic Chemistry, 1974J P, Gillespie +2 more
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