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A novel route for the synthesis of 1-benzoxepins and some of their reactions

open access: yes
Brannock   +12 more
core   +1 more source
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Tetrahydro-2-benzoxepins: a novel family of hypotensives

Journal of Medicinal Chemistry, 1981
A novel series of 1-(alkylamino)-1,3,4,5-tetrahydro-7,8-dimethoxy-2-benzoxepins shows hypotensive activity. A typical example is 1-[2-(1,3,4,5-tetrahydro-7,8-dimethoxy-2-benzoxepin-1-yl)ethyl]-4-(4-fluorophenyl)piperazine. This compound is an alpha blocker with peripheral and central activities.
R E, TenBrink   +6 more
exaly   +5 more sources

Gold(i)-catalyzed diastereo- and enantioselective [4 + 3] cycloadditions: construction of functionalized furano-benzoxepins

Organic Chemistry Frontiers, 2022
Enantioselective higher-order cycloaddition involving gold-furyl 1,3-dipoles is an attractive but challenging transformation for the construction of chiral polycyclic medium-sized rings from readily available building blocks.
Xiaoxun Li
exaly   +2 more sources

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