Results 21 to 30 of about 3,130 (254)

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Family Assets and Financial Misfortunes of the Castellví Family during the 17th Century

Studia Historica: Historia Moderna, 2014
The valencian branch of the Castellví family, which was started in the early five hundreds by the Lord of Puchol, took part in a significant asset accumulation process during the seventeenth century.
Amparo FELIPO ORTS
doaj   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

Towards Defect Phase Diagrams: From Research Data Management to Automated Workflows

Advanced Engineering Materials, EarlyView.
A research data management infrastructure is presented for the systematic integration of heterogeneous experimental and simulation data required for defect phase diagrams. The approach combines openBIS with a companion application for large‐object storage, automated metadata extraction, provenance tracking and federated data access, thereby supporting ...
Khalil Rejiba, Sang‐Hyeok Lee, Christina Gasper, Martina Freund, Sandra Korte‐Kerzel, Ulrich Kerzel   +5 more
wiley   +1 more source

Current Status and Challenges in Data Collection for Aerospace Coatings Deposited by Plasma Spraying

Advanced Engineering Materials, EarlyView.
An innovative approach has been integrated into the GRENAT project to optimize plasma spraying and coating performance. Raw materials are accelerated and melted in the plasma generated by torches, creating coatings. Monitoring sensors collect process data which are combined with ex situ characterization data.
Lila Randriamananjara, Vincent Rat, Quentin Dubreuil, Patrice Valorge, Simon Goutier, Alain Denoirjean, Olivier Messe, Céline Ruelle, Jean‐Philippe Poli   +8 more
wiley   +1 more source

Testamentary Bequests for Pious Purposes in the Christian Roman Empire

Journal on European History of Law, 2010
The document explores the legal capacity of the church to receive bequests for pious purposes within the Christian Roman Empire. It delves into the foundational case where the church was designated as the heir or was bequeathed a legacy or a fiduciary ...
Pál Sáry
doaj   +2 more sources

Mendicant Orders in Medieval Prussia and Livonia: Pastoral Activities in Towns

Acta Historica Universitatis Klaipedensis, 2016
The paper presents the general conditions in which the pastoral work of mendicant orders was conducted in the domains of the Teutonic Order and particular bishoprics in Prussia and Livonia, at the same time indicating similarities and differences in the ...
Rafał Kubicki
doaj   +1 more source

Minimally Invasive Delivery of Optical Nanosensors Using Injectable Hydrogels

Advanced Materials Interfaces, EarlyView.
Injectable peptide hydrogels offer a minimally invasive delivery platform for single‐walled carbon nanotube (SWCNT)‐based near‐infrared fluorescent sensors, enabling real‐time measurement of drug concentrations. Encapsulated SWCNTs show a dose‐dependent fluorescence response across physiologically relevant concentrations and retain their fluorescence ...
Shirel Kleiner, Gili Bisker
wiley   +1 more source

Legaty testamentowe mieszczan krakowskich na rzecz kościoła i klasztoru bernardynów na Stradomiu w drugiej połowie XV wieku

Kwartalnik Historii Kultury Materialnej, 2015
CRACOW BURGHERS’ BEQUESTS TO THE OBSERVANTS’ FRIARY IN STRADOMIN THE SECOND HALF OF THE 15TH C. The article is aimed at analysing late-mediaeval testaments of Cracow burghers which included bequests to the Observants’ church and friary in Stradom (a ...
Urszula Zachara-Związek
doaj