Results 101 to 110 of about 405,602 (197)

Motivos para la documentación de lenguas en vías de extinción

Forma y Función, 2000
En este artículo se tratan algunas cuestiones teóricas que surgen del reconocimiento de que dentro de pocos años, la diversidad lingüística a nivel mundial se va a disminuir drásticamente. Por un lado, hay que investigar las causas, síntomas y efectos de
Frank Seifart
doaj  

Cell Cycle Control of Nuclear Metabolism Couples Phosphatidylinositol Signaling to Histone Methylation

Advanced Science, EarlyView.
Nuclear metabolism oscillates during cell cycle progression. Quantitative chromatome proteomics and imaging reveal phase‐specific dynamics of PIP5K1A and nuclear PIP2, linking phosphatidylinositol metabolism to histone methylation. This work identifies nuclear lipid metabolism as a previously unrecognized regulatory axis coordinating chromatin ...
Antoni Gañez‐Zapater, Savvas Kourtis, Camilla Reiter Elbæk, Lorena Espinar, Carolina Toro‐Márquez, Albert Coll‐Manzano, Alfredo Smiriglia, Laura García‐López, Laura Wiegand, Maria Guirola, Frédéric Fontaine, Andrea Morandi, André C. Müller, Sara Sdelci   +13 more
wiley   +1 more source

Cold Orthogonal Translation: A Psychrophilic Pyrrolysyl‐tRNA Synthetase Boosts Genetic Code Expansion in E. coli

Advanced Science, EarlyView.
ABSTRACT Orthogonal translation systems (OTSs) enable site‐specific incorporation of non‐canonical amino acids (ncAAs) and are central to genetic code expansion. Current engineering strategies typically rely on hyperstable aminoacyl tRNA synthetase (aaRS) scaffolds to tolerate destabilizing mutations required for substrate diversification.
Nikolaj G. Koch, Peter Goettig, Michael A. Nash, Juri Rappsilber, Nediljko Budisa   +4 more
wiley   +1 more source

Three-territory sign in infective endocarditis and concomitant stroke: a retrospective analysis on characteristics and associated factors. [PDF]

Neurol Res Pract
Schuermann H, von Rennenberg R, Riegler C, Hellwig S, Stengl H, Litmeier S, Scheitz JF, Doehner W, Audebert H, Braemswig TB, Nolte CH.   +10 more
europepmc   +1 more source

Diversity of Pharmaceuticals Enhances Antibiotic Resistance in the Invertebrate Gut via Biofilm‐Mediated Mechanisms

Advanced Science, EarlyView.
Pharmaceutical diversity acts as an independent driver of antibiotic resistance in soil invertebrates. While bulk soil remains unaffected, the collembolan gut microbiome exhibits significant resistance gene enrichment under complex chemical exposure and diurnal warming.
Yi‐Fei Wang, Ya‐Ning Wang, Da Lin, Jia‐Yang Xu, Feng‐Yuan Qi, Hui‐Ling Cui, Hui‐Jie Lu, Min Qiao, Edward Topp, Dong Zhu, Matthias C. Rillig, Yong‐Guan Zhu   +11 more
wiley   +1 more source

Impact of culture dimensionality and matrix composition on morphology, phenotype and drug response in pancreatic cancer models. [PDF]

Sci Rep
Doelvers F, Wansch K, Kuehn A, Dragomir MP, Janik T, Joosten M, Hilfenhaus G, Vecchione L, Felsenstein M, Ma D, Lerchbaumer M, Jürgensen C, Bahra M, Duwe G, Stintzing S, Keilholz U, Pelzer U, Neumann CCM.   +17 more
europepmc   +1 more source

Diminished Signal‐to‐Noise Ratio Disrupts Somatosensory Population Encoding and Drives Tactile Hyposensitivity in the Fmr1−/y Autism Model

Advanced Science, EarlyView.
This study provides a translational approach for linking neural activity to tactile deficits in autism. By combining psychophysics with cortical recordings in a mouse model of autism, we show that low signal‐to‐noise ratio in somatosensory neurons weakens population encoding of fine touch, impairing detection, decoding, and leading to perceptual ...
Ourania Semelidou, Théo Gauvrit, Célien Vandromme, Alexandre Cornier, Anna Saint‐Jean, Yves Le Feuvre, Melanie Ginger, Andreas Frick   +7 more
wiley   +1 more source

Correction: Collaborative neurocardiology board meetings for decision-making in stroke care: a real-world experience. [PDF]

Neurol Res Pract
Mafael V, Buck T, Stengl H, Hellwig S, Klammer MG, Endres M, Reinthaler M, Barbieri F, Audebert HJ, Leistner DM, Landmesser U, Doehner W, Skurk C, Scheitz JF.   +13 more
europepmc   +1 more source

Nanoscale Spatial Organization of ARC High‐ and Low‐Order Assemblies at Excitatory Synapses

Advanced Science, EarlyView.
ARC (Activity‐Regulated Cytoskeleton‐Associated protein) mediates synaptic plasticity by forming nanoscale assemblies in neurons. Using super‐resolution microscopy and time‐resolved anisotropy with targeted tagging, the study reveals low‐order ARC assemblies at synapses colocalizing with AMPARs, semi‐circular structures at endocytic zones, and 60–80 nm
Martina Damenti, Giovanna Coceano, Mariline Mendes Silva, Jonatan Alvelid, Chiara Sgattoni, Andrea Volpato, Lea Rems, Luciano A. Masullo, Eduard M. Unterauer, Rafal Kowalewski, Lucie Delemotte, Erdinc Sezgin, Ralf Jungmann, Ilaria Testa   +13 more
wiley   +1 more source

Author Correction: Reproductive individuality of clonal fish raised in near-identical environments and its link to early-life behavioral individuality. [PDF]

Nat Commun
Scherer U, Ehlman SM, Bierbach D, Krause J, Wolf M.   +4 more
europepmc   +1 more source