Results 161 to 170 of about 414,254 (263)

A Synthetic β‐Mannan Epitope Enables Immunization and Detection of Candida auris

Angewandte Chemie, EarlyView.
A synthetic β‐mannan epitope enables both active and passive immunization against Candida auris. Conjugation to the carrier protein CRM197 induces protective antibody responses, while monoclonal antibodies targeting the same epitope support detection using a lateral flow assay, linking glycochemistry with antifungal prevention and diagnostics ...
Emelie E. Reuber, Arnab Pradhan, Ian Leaves, Rajat K. Singh, Emer Hickey, Carola Geiler, Neil A. R. Gow, Alistair J. P. Brown, Peter H. Seeberger   +8 more
wiley   +2 more sources

Liquid biopsy-based detection of acquired MET resistance enables sequential targeted therapy in MET fusion-positive NSCLC. [PDF]

Oncologist
Rosnev S, Klein K, Heukamp L, Lenk J, Joosten M, Möbs M, Grob T, Benary M, Vecchione L, Ott CE, Modest DP, Knödler M, Keller U, Frost N, Keilholz U, Kiewe P, Rieke DT.   +16 more
europepmc   +1 more source

Untersuchung von Anti‐Glykan‐Antikörpern und Erforschung ihres medizinischen Potenzials mithilfe synthetischer Glykane

Angewandte Chemie, EarlyView.
Anti‐Glykan‐Antikörper spielen sowohl bei Gesundheit als auch bei Krankheit eine wesentliche Rolle. Der Zugang zu neuartigen Glykanstrukturen ermöglicht Fortschritte bei der Antikörpercharakterisierung für die Entdeckung von Biomarkern, die Antikörperentwicklung und das Impfstoffdesign.
Fabienne Weber, Aina Valenti, Jiří Ledvinka, Oren Moscovitz, Peter H. Seeberger   +4 more
wiley   +1 more source

Cycloazulenylene

Angewandte Chemie International Edition, EarlyView.
A strained macrocycle consisting solely of azulene subunits, named [6]cycloparaazulenylene ([6]CPA), is presented. The macrocycle exhibits a notably narrow HOMO–LUMO gap for a pristine azulene species, strain‐induced red‐shifted absorption, and an unusual tubular packing motif elucidated via single‐crystal XRD.
Clara Douglas, Josefine Sprachmann, David Dunlop, Joël Schlecht, Jörg Neudörfl, Tommy Wachsmuth, Julian Frost, Tomáš Slanina, Oliver Dumele   +8 more
wiley   +1 more source

Fine-scale heterogeneity and local amplification of West Nile virus in urban environments in Berlin. [PDF]

Nat Commun
Patzina-Mehling C, Kopp A, Lee YS, Birkl MXL, Ebers S, Voigt K, Graff SL, Beisel U, Landgraf C, Ganz F, Planillo A, Kramer-Schadt S, Junglen S.   +12 more
europepmc   +1 more source

Separation and Valorization of Chlorine From Tail Gas Streams

Angewandte Chemie International Edition, EarlyView.
A commercially available ion exchange resin was found to adsorb chlorine gas selectively in the presence of other gases reversibly forming the corresponding trichloride species [IEx][Cl3]. This discovery was telescoped to an efficient process for the recycling and valorization of chlorine from industrially abundant tail gas streams to base chemicals ...
Gesa H. Dreyhsig, Merlin Kleoff, Patrick Voßnacker, Elisabeth Dorn, Jacob H. Richter, Sebastian Riedel   +5 more
wiley   +1 more source

Minute‐Scale Repeated Metabolic Probing of Living Cells Enabled by Rapid Parahydrogen‐Based Hyperpolarization

Angewandte Chemie International Edition, EarlyView.
Rapid parahydrogen hyperpolarization combined with simple dilution enables biocompatible delivery of hyperpolarized pyruvate to immobilized living cells within ≈1 min. Repeated substrate injections reveal frequency‐dependent metabolic dynamics, introducing a new temporal dimension for hyperpolarized NMR studies of cellular metabolism and enabling rapid
Philipp R. Groß, Stefan Petersen, Zirun Wang, Behnam Shamshiri, Henri de Maissin, Sebastian Lucas, Oliver Gorka, Lisa Heß, Irene Marco‐Rius, Lluís Mangas‐Florencio, André F. Martins, Philipp Boehm‐Sturm, Maxim Zaitsev, Robert Zeiser, Jan‐Bernd Hövener, Thomas Reinheckel, Olaf Groß, Andreas B. Schmidt   +17 more
wiley   +1 more source

Discovery of an Antiviral Electron Transfer Process to Create Catalytically Self‐Sufficient Viral Restriction Factors

Angewandte Chemie International Edition, EarlyView.
CYB5R3 is identified as a putative electron‐transfer partner of viperin (RSAD2), explaining why ER localisation is required for antiviral activity. Its utilisation enabled the engineering of immune‐silent, catalytically self‐sufficient antiviral restriction factor enzymes (iCAREs) that produce an antiviral nucleoside triphosphate analogue (ANTA ...
Mengdi Wu, Nghi Thao Hoang, Deborah Grifagni, Meritxell Wu‐Lu, Yujie Sheng, Theo Situmorang, Pei‐Hsin Tai, Zheng Chen, Astrid Maluta, Mohammed Hakil, Bianca Susini, Hannah Florance, Peter‐Leon Hagedoorn, John Mark Sutton, Maria‐Andrea Mroginski, Simone Ciofi‐Baffoni, Kourosh H. Ebrahimi   +16 more
wiley   +1 more source

Sequential visual stimuli increase high frequency power in the visual cortex. [PDF]

Sci Rep
Keil J, Hernandez-Urbina V, Vassiliou C, Dean C, Schmitz D, Kremkow J, Sibille J.   +6 more
europepmc   +1 more source

Author Correction: Pharmacological markers of HIV prevention for oral pre-exposure prophylaxis in men who have sex with men. [PDF]

Nat Commun
Iannuzzi S, Müller M, Yu Y, Zhang L, Hendrix CW, Bies RR, von Kleist M.   +6 more
europepmc   +1 more source