Results 41 to 50 of about 687,193 (297)

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Architectural Competitions as an Instrument for ‘Urban Rationalization' in the Context of the Discourse of ‘Consistency' in Modernity; the Case of Berlin

Megaron, 2016
This article discusses some architectural and urban design competition projects, as well as the ideas that influenced them, which have had a significant place in the development of Berlin since World War II.
Evin Eriş, Doç. Dr. Yasemen Say Özer
doaj   +1 more source

Co-Creation of Local Development and Effective Public Participation. Sozialer Zusammenhalt („Social Cohesion”) Programme in Berlin as an Example of Practice

Polish Political Science Yearbook, 2023
Co-creation of public policy can be considered a democratic innovation, all the more so as this approach seems to secure the possibility of „redefining what is democracy”. Understood this way, it is a direct source of changes in urban governance systems.
Aldona Wiktorska-Święcka
doaj   +1 more source

Urban Rainfall Modification: Observational Climatology Over Berlin, Germany

Journal of Geophysical Research: Atmospheres, 2019
This study investigates the direct influence of urban areas on storm events (heavy rainfall above 17 mm/hr). An 11‐year climatology of summertime precipitation was performed to capture and describe storm events for Berlin, Germany.
Judith M. Lorenz, R. Kronenberg, C. Bernhofer, D. Niyogi   +3 more
semanticscholar   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Implementation of the 2017 Berlin Concussion in Sport Group Consensus Statement in contact and collision sports: a joint position statement from 11 national and international sports organisations

British Journal of Sports Medicine, 2018
The 2017 Berlin Concussion in Sport Group Consensus Statement provides a global summary of best practice in concussion prevention, diagnosis and management, underpinned by systematic reviews and expert consensus. Due to their different settings and rules,
J. Patricios, C. Ardern, Michael Hislop, M. Aubry, Paul Bloomfield, C. Broderick, P. Clifton, R. Echemendia, R. Ellenbogen, É. Falvey, G. Fuller, Julie Grand, D. Hack, P. Harcourt, D. Hughes, N. McGuirk, W. Meeuwisse, Jeffrey T. Miller, John T. Parsons, Simona Richiger, Allen K. Sills, K. Moran, J. Shute, M. Raftery   +23 more
semanticscholar   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Self-organised urban space without profit: Four Examples in Berlin

PlaNext, 2017
The following article explores the interdependency between urban crisis as a pre-condition for self-organised responses to it and self-organised projects that try to provide solutions for problems caused by the respective crisis.
Stephan Schwarz, Ingrid Sabatier-Schwarz
doaj   +1 more source