Results 191 to 200 of about 52,295 (312)

Synergistic HMGN1 and VP64 Fusions Potentiate High‐Precision and PAM‐Flexible Base Editing

Advanced Science, EarlyView.
A novel CDA1Δ‐SpRY architecture fused with HMGN1 and VP64 yields a nearly PAM‐less base editing platform. By focusing cytosine conversion predominantly at position −18, this synergistic complex ensures highly precise targeting. Demonstrating enhanced efficiency across diverse models, including yeast and rice, the platform offers a robust solution for ...
Xi Luo, Yuyao Qu, Zhengyan Ye, Zheng Li, Yuanyan Zhang, Longjiong Luo, Shaokang Li, Wei Zhao, Ming Wang, Ralph Bock, Jianmin Wan, Junjie Tan   +11 more
wiley   +1 more source

Triple base editor catalyzes saturation mutation of adenine, cytidine, and guanine. [PDF]

Nucleic Acids Res
Wu Y, Wang J, Zhang Z, Shang M, Wang S, Li Y, Li G, Lu S, Ji K, Wang X, Zhang X.   +10 more
europepmc   +1 more source

Placental Site Trophoblastic Tumor Acquires Immune Functions by Incorporating Host Maternal Genes

Advanced Science, EarlyView.
PSTT cells, through cell fusion with B cells, incorporate abundant non‐inherited maternal genes that are detectable by DNIMA. These hybrid cells acquire immunotherapy‐resistant genetic changes and increase the expression of B cell‐derived immune‐related molecules such as Ig, HLA, LILRB, SIGLEC10, and so on, creating an immunotolerant environment around
Kyosuke Kagami, Masanori Ono, Yasunari Mizumoto, Tatsuhito Kanda, Takashi Iizuka, Takiko Daikoku, Shin‐ichi Horike, Akira Hattori, Akihito Horie, Sachiko Minamiguchi, Tomoko Fujiwara, Kazuyoshi Hosomichi, Atsushi Tajima, Hirokazu Usui, Kaoru Abiko, Hiroshi Fujiwara   +15 more
wiley   +1 more source

Participatory Scenario Design to Support Ex-ante Biodiversity and Ecosystem Services Assessments in Four European Agricultural Case Studies. [PDF]

Environ Manage
Karner K, Suškevičs M, Danzinger F, Kay S, Bethwell C, Klein N, Nishizawa T, Schuler J, Glemnitz M, Zander P, Conradt T, Sepp K, Semm M, Hämäläinen L, Raet J, Värnik R, Villoslada M, Wrbka T, Schönhart M.   +18 more
europepmc   +1 more source

Being a doctor, being human

Archivos Argentinos de Pediatria, 2016
openaire   +2 more sources

Micro‐Galvanic Coupling Programs the Therapeutic Zinc Ion Window to Reconfigure Immune Cascades for Pro‐Regenerative Bone Healing

Advanced Science, EarlyView.
This study utilized alloy micro‐galvanic coupling design to regulate the release of essential elements, thereby programming immune responses and promoting regeneration. The sacrificial anodic process of Zn‐0.8Mg reduced Zn2+ release compared to the “large cathode‐small anode” coupling of Zn‐0.8Fe.
Chaoyang Sun, Bo Jia, Jiahui Shi, Shuang Li, Guo Bao, Dong Bian, Kai Chen, Junlong Tan, Xuenan Gu, Yan Guan, Yu Qin, Xinhua Qu, Xiaogang Wang, Yufeng Zheng, Hongtao Yang   +14 more
wiley   +1 more source

PID Control for Uncertain Systems with Integral Measurements and DoS Attacks Using a Binary Encoding Scheme. [PDF]

Entropy (Basel)
Hou N, Wu Y, Gao H, Hu Z, Bu X.
europepmc   +1 more source

Being Strange While Being No One [PDF]

Frontiers in Psychology, 2018
openaire   +4 more sources

Biointegrated Multilayer Stretchable OLED Platform With Strain‐Decoupled Architecture for Durable Phototherapeutic Applications

Advanced Science, EarlyView.
A multilayer stretchable organic light‐emitting diode (SOLED) patch enables conformal, high‐fill‐factor phototherapeutic illumination through vertically decoupled electrodes and robust encapsulation. The textile‐based SOLED platform delivers stable skin‐contact red light for wearable phototherapy and 5‐aminolevulinic acid (ALA)‐mediated photodynamic ...
Young Hyun Son, Myeongheon Lee, Jun‐Yeop Song, Hyo‐Jung Kwon, Kyung Cheol Choi, Jeong Hyun Kwon   +5 more
wiley   +1 more source

Hybrid Assistive Limb Single Joint Type (HAL-SJ) Training for Knee Osteoarthritis: A Case Series. [PDF]

Cureus
Tanaka M, Soma Y, Shimizu Y, Kikuchi N, Kadone H, Yamazaki M, Mishima H, Hada Y.   +7 more
europepmc   +1 more source