Results 21 to 30 of about 25,687 (214)

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

open access: yesFEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa   +2 more
wiley   +1 more source

De este a oeste. Un colgante del siglo iv a. C. que apunta una vía de comunicación [PDF]

open access: yesBoletín del Museo Arqueológico Nacional, 2018
Se presenta un colgante de bronce calado con la representación esquemática y casi simétrica de una figura antropomorfa, que suele interpretarse como una divinidad relacionada con los animales.
Magdalena Barril Vicente
doaj  

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

open access: yesFEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee   +7 more
wiley   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

open access: yesFEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens   +8 more
wiley   +1 more source

BİREYSEL EMEKLİLİK SİSTEMİNDE ESKİ VE YENİ TEŞVİK DÜZENLEMELERİ ÜZERİNE KARŞILAŞTIRMALI BİR DEĞERLENDİRME

open access: yesMehmet Akif Ersoy Üniversitesi İktisadi ve İdari Bilimler Fakültesi Dergisi, 2014
Bu çalışmanın konusunu, Yeni Bireysel Emeklilik Sisteminin (BES) değerlendirilmesi ve BES teşvik sisteminde yapı-lan değişikliklerin incelenmesi oluşturmaktadır. Çalışma beş bölümden oluşmaktadır: Birinci bölümde, genel hatları ile Türkiye’de BES’e neden
Göknur Büyükkara, Mehmet Balcı
doaj   +2 more sources

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

open access: yesFEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi   +6 more
wiley   +1 more source

The effects of silage additive on the microbial succession and fermentation products during ensiling period and in corn silage [PDF]

open access: yesEurasian Journal of Veterinary Sciences
This study was conducted to determine the effect of additive teatment on microbial succession and fermentation characteristics during d 8 (0,2,4,8) of ensilimng period of com for silage and changes of nutrients contents, fermentation products and in ...
Kazım Şahin   +4 more
doaj  

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

open access: yesFEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt   +8 more
wiley   +1 more source

The effect of chloramhenicol on production of laying hens and determination of chloramphenicol residues in eggs [PDF]

open access: yesEurasian Journal of Veterinary Sciences
This study was conducted to the effect of chloramhenicol on the e gig production of the laying hens and the residue levels in the eggs. Laying hens in four groups of 30 were fed on a diet containing chloramphenicol 0 ppm (group I), 20 ppm (group II) and ...
Ahmet ACET   +5 more
doaj  

Translophagy—A potential link between autophagy impairment and translational errors

open access: yesFEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk   +11 more
wiley   +1 more source

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