Results 61 to 70 of about 179,040,826 (293)
, 2019 This contribution aims to investigate the systemic role of the Best Interests of the Child principle in contemporary international family law. For private international law and international human rights law, the Principle, as expression of a progressive
Distefano M.
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Three perspectives on the notion of ‘the best interests of the child’
In die SkrifligThe research reported in this article was centred on three research questions about the issue of ensuring that, in education and schooling, the principle of the best interests of the child is respected.
Johannes L. Van der Walt +1 more
doaj +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Best interests of the child in refugee status determination [PDF]
This thesis investigates how the best interests of the child, as outlined in Article 3(1) of the United Nations Convention on the Rights of the Child, should be taken into account in refugee status determinations (RSD) conducted by states under the ...
Vartiainen, Venla
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Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Representing the child: the evolution of the guardian ad litem in care proceedings [PDF]
, 1993 The aim of the study is to illuminate the legal, social and administrative context of the "safeguarding" and representational role of the guardian ad litem in care proceedings, a senior social worker appointed by the court to represent
Cooper, Susan A.M.
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The Best Interests of the Child assessment with recently arrived refugee children [PDF]
, 2016 In 2014, the United Nations Convention on the Rights of the Child (UNCRC) celebrated its 25th anniversary. While the best interests of the child have for a much longer time been a major concern for professionals working with children, the UNCRC gave ...
van Os, Carla
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PANoptosis in the pathogenesis of myelodysplastic syndromes
Molecular Oncology, EarlyView.PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla +4 more
wiley +1 more source
The late discovery of adoptive and donor insemination offspring status : ethical implications for conceptual understandings of the ‘best interests of the child’ principle\ud [PDF]
, 2012 Late discovery is a term used to describe the experience of discovering the truth of one’s genetic origins as an adult. Following discovery, late discoverers face a lack of recognition and acknowledgment of their concerns from family, friends, community ...
Riley, Helen J.
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Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation
Molecular Oncology, EarlyView.How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim +11 more
wiley +1 more source