Results 221 to 230 of about 190,253 (294)

Mass Spectrometry Structural Proteomics Enabled by Limited Proteolysis and Cross‐Linking

open access: yesMass Spectrometry Reviews, EarlyView.
ABSTRACT The exploration of protein structure and function stands at the forefront of life science and represents an ever‐expanding focus in the development of proteomics. As mass spectrometry (MS) offers readout of protein conformational changes at both the protein and peptide levels, MS‐based structural proteomics is making significant strides in the
Haiyan Lu   +4 more
wiley   +1 more source

Machine Learning for Predictive Modeling in Nanomedicine‐Based Cancer Drug Delivery

open access: yesMed Research, EarlyView.
The integration of AI/ML into nanomedicine offers a transformative approach to therapeutic design and optimization. Unlike conventional empirical methods, AI/ML models (such as classification, regression, and neural networks) enable the analysis of complex clinical and formulation datasets to predict optimal nanoparticle characteristics and therapeutic
Rohan Chand Sahu   +3 more
wiley   +1 more source

Multimodal Imaging Investigation of the Dentato‐Thalamo‐Cortical Pathway in Friedreich's Ataxia

open access: yesMovement Disorders, EarlyView.
Abstract Background Friedreich's ataxia (FRDA) is a spinocerebellar neurodegenerative disorder. The dentato‐thalamo‐cortical (DTC) pathway, an important cerebellar output involved in motor control, plays a crucial role in the neural mechanisms underlying ataxia symptoms in FRDA.
Yinghua Jing   +22 more
wiley   +1 more source

Assessment of Optimal T1/T2‐Weighted Combinations for Myelin Sensitivity: Effects of Echo Time and Exponents

open access: yesMagnetic Resonance in Medicine, EarlyView.
ABSTRACT Purpose The aim of this study is to improve the traditional T1‐weighted (T1w) over T2‐weighted (T2w) ratio as a proxy for myelin by investigating the optimal T2w TE and combination of exponent‐weighted T1w and T2w images (T1wx1/T2wx2$$ \mathrm{T}1{\mathrm{w}}^{x_1}/\mathrm{T}2{\mathrm{w}}^{x_2} $$).
Simone Monachino   +7 more
wiley   +1 more source

Simultaneous Volumetric T1 and T2 Mapping With Blood‐ and Fat‐Suppression in Abdominal Aortic Aneurysms

open access: yesMagnetic Resonance in Medicine, EarlyView.
ABSTRACT Purpose To develop and validate a protocol for simultaneous volumetric T1 and T2 mapping with blood‐ and fat‐suppression, and apply it to patients with abdominal aortic aneurysms (AAA) to assess tissue characteristics. Methods A spoiled gradient echo (SPGR) variable flip angle (VFA) acquisition was modified with preparation modules to suppress
Wilhelm Stehling   +7 more
wiley   +1 more source

Home - About - Disclaimer - Privacy