Results 91 to 100 of about 7,710 (298)

Gastrula‐Premarked Posterior Enhancer Primes Posterior Tissue Development Through Cross‐Talk with TGF‐β Signaling Pathway

Advanced Science, EarlyView.
A gastrula‐premarked enhancer within the first intron of Cdx2 governs posterior embryonic development via both regulating Cdx2 expression in cis and coordinating TGF‐β signaling in trans to ensure proper posterior body development. Functional rescue in gastruloids reveals a Cdx2‐independent pathway, highlighting p‐Enh‐eRNA as key epigenetic ...
Yingying Chen, Fengxiang Tan, Qing Fang, Lin Zhang, Jiaoyang Liao, Penglei Shen, Yun Qian, Mingzhu Wen, Rui Song, Yonggao Fu, He Jax Xu, Ran Wang, Cheng Li, Zhen Shao, Jinsong Li, Naihe Jing, Xianfa Yang   +16 more
wiley   +1 more source

Best linear unbiased estimation of the Fourier coefficients of periodic signals

IEEE Transactions on Instrumentation and Measurement, 1993
Fourier coefficients of periodic signals are usually estimated by the discrete Fourier transform (DFT). Since DFT is equivalent to ordinary least squares, it might be expected to be best linear unbiased only if the errors in the observations are not covariant. Fortunately, for covariant errors, the DFT achieves this optimum property asymptotically. >
openaire   +4 more sources

Capacity Estimation and Knee Point Prediction Using Electrochemical Impedance Spectroscopy for Lithium Metal Battery Degradation via Machine Learning

Advanced Science, EarlyView.
This work explores a machine learning (ML) model with electrochemical impedance spectroscopy (EIS) data to address two critical challenges in Lithium metal batteries (LMBs): capacity degradation trajectory and knee point (KP) estimation, for the first time.
Qianli Si, Shoichi Matsuda, Yasunobu Ando, Toshiyuki Momma, Yoshitaka Tateyama   +4 more
wiley   +1 more source

A New Bound for the Euclidean Norm of the Difference Between the Least Squares and the Best Linear Unbiased Estimators [PDF]

, 1980
Jerzy K. Baksalary, Radosław Kala
openalex   +1 more source

deepTFBS: Improving within‐ and Cross‐Species Prediction of Transcription Factor Binding Using Deep Multi‐Task and Transfer Learning

Advanced Science, EarlyView.
DeepTFBS leverages deep learning to predict transcription factor binding sites across species, integrating multi‐task and transfer learning approaches to improve performance in data‐scarce scenarios. This study demonstrates enhanced accuracy in intra‐ and cross‐species prediction, revealing conserved regulatory patterns and functional variants.
Jingjing Zhai, Yuzhou Zhang, Chujun Zhang, Xiaotong Yin, Minggui Song, Chenglong Tang, Pengjun Ding, Zenglin Li, Chuang Ma   +8 more
wiley   +1 more source

Amyloid Forming Human Lysozyme Intermediates are Stabilized by Non‐Native Amide‐π Interactions

Advanced Science, EarlyView.
Mutational variants of human lysozyme cause fatal systemic amyloidosis by depositing kilograms of protein in the viscera of patients. Central to this process is a partially unfolded protein intermediate state that initiates aggregation into amyloid fibrils.
Minkoo Ahn, Julian O. Streit, Christopher A. Waudby, Tomasz Włodarski, Angelo Miguel Figueiredo, John Christodoulou, Janet R. Kumita   +6 more
wiley   +1 more source

Single‐Cell Transcriptome Profiling Reveals Conserved IFNγ‐IL8 Signaling‐Induced Antibacterial Neutrophil States during Bacterial Infection

Advanced Science, EarlyView.
SummaryThis study constructs a single‐cell immune atlas of Nile tilapia across multiple time points during Streptococcus agalactiae infection, revealing dynamic immune cell responses and subtype transitions. It identifies a conserved IFNr‐STAT1‐IL8 axis driving il8+ neutrophils activation and antibacterial function, supported by cross‐species ...
Xue Zhai, Minghao Zhang, Kang Li, Wei Li, Xiaolong Li, Wa Gao, Zhaosheng Sun, Dan Huang, Songqian Huang, Mingli Liu, Zhichao Wu, Jun Zou, Liangbiao Chen, Jialong Yang, Peng Hu   +14 more
wiley   +1 more source

AllInOne Pre-processing: A comprehensive preprocessing framework in plant field phenotyping

SoftwareX, 2023
AllInOne Pre-processing is an innovative open-source, R-Shiny user interface package designed to facilitate the swift and effective preprocessing of plant phenotypic data.
Mohsen Yoosefzadeh Najafabadi, Ali Heidari, Istvan Rajcan   +2 more
doaj  

Lysosomal Cathepsin S Escape Facilitates Near Infrared Light‐Triggered Pyroptosis Via an Antibody‐Indocyanine Green Conjugate

Advanced Science, EarlyView.
ICAM1 antibody‐bound ICG triggers tumor‐specific, caspase‐1‐independent pyroptosis via CTSS‐mediated GSDMD cleavage, activates antitumor immunity, and synergizes with anti–PD‐1 therapy, offering a non‐apoptotic strategy to overcome resistance in cancer treatment.
Fan Chen, Xue‐Fei Tian, Teng Yang, Yu‐Jie Dai, Da‐Yuan Chen, Hong‐Bo Chen, Takaya Shimura, Xin‐Fang Li, Chu‐Lin Sha, Qing Ji, Jun Cao, Mei‐Yu Fang, Jin‐Biao Shang, Jian‐Min Fang, Ye Lu, Wei‐Hui Zheng, Peng Guo, Wei‐Hong Tan   +17 more
wiley   +1 more source

SGCD: High‐Resolution Spatial Domain Characterization via Data Interpolation and Cell‐Type Deconvolution

Advanced Science, EarlyView.
SGCD presents a novel approach for tissue spatial domain identification by employing interpolation to estimate inter‐spot gene expression and deconvolution to resolve cell‐type composition in both sampled and interstitial regions. By integrating gene expression, cell type, and spatial coordinates within a graph contrastive learning framework, SGCD ...
Tianjiao Zhang, Shenghe Li, Ruolan Zhang, Hongfei Zhang, Zhongqian Zhao, Hao Sun, Zhenao Wu, Guohua Wang   +7 more
wiley   +1 more source