Results 31 to 40 of about 62,351 (294)

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

Molecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad, Mahmood Hachim, Tom Bertin, Karolina Penderecka, Rifat Hamoudi, Saif Khan, Rui Henrique, Natalie Bergmoser, Manit Arya, Kalle Sipila, Matteo Vietri Rudan, Asif Muneer, Aamir Ahmed   +12 more
wiley   +1 more source

Weighted Moments Estimators of the Parameters for the Extreme Value Distribution Based on the Multiply Type II Censored Sample

The Scientific World Journal, 2013
We propose the weighted moments estimators (WMEs) of the location and scale parameters for the extreme value distribution based on the multiply type II censored sample.
Jong-Wuu Wu, Sheau-Chiann Chen, Wen-Chuan Lee, Heng-Yi Lai   +3 more
doaj   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Systematic bias of selected estimates applied in vertical displacement analysis

Journal of Geodetic Science, 2020
In surveying problems we almost always use unbiased estimators; however, even unbiased estimator might yield biased assessments, which is due to data.
Wyszkowska P., Duchnowski R.
doaj   +1 more source

Best Linear Unbiased Estimators for Repeated Surveys

Journal of the Royal Statistical Society Series B: Statistical Methodology, 1980
Summary Recent work on the problem of obtaining best linear unbiased estimators from a sample survey which is repeated on several occasions has centred on the effects of extending the model assumptions to allow for stochastic variation in the parameters being estimated.
openaire   +2 more sources

Pathogenic Neurofibromatosis type 1 gene variants in tumors of non‐NF1 patients and role of R1276

FEBS Open Bio, EarlyView.
Somatic variants of the neurofibromatosis type 1 (NF1) gene occur across neoplasms without clinical manifestation of the disease NF1. We identified emerging somatic pathogenic NF1 variants and hotspots, for example, at the arginine finger 1276. Those missense variants provide fundamental information about neurofibromin's role in cancer.
Mareike Selig, Swanhild Lohse, Sara Elahi, Nils Hartmann, Stefanie Deckert, Shutian Si, Alexander Desuki, Anja Harder   +7 more
wiley   +1 more source

PENDUGAAN PARAMETER REGRESI ROBUST METODE MINIMUM COVARIANCE DETERMINANT DAN METODE TELBS

E-Jurnal Matematika, 2023
The parameter estimator on the regression model can be obtained through the ordinary least square (OLS). When there are outliers in the data, OLS cannot be applied because it will produce an unbiased estimator that is not the best linear estimator ...
NI KETUT ZELINA YERISKA, I GUSTI AYU MADE SRINADI, I KOMANG GDE SUKARSA   +2 more
doaj   +1 more source

Discovery and Targeted Proteomic Studies Reveal Striatal Markers Validated for Huntington's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Clinical trials for Huntington's disease (HD) enrolling persons before clinical motor diagnosis (CMD) lack validated biomarkers. This study aimed to conduct an unbiased discovery analysis and a targeted examination of proteomic biomarkers scrutinized by clinical validation. Methods Cerebrospinal fluid was obtained from PREDICT‐HD and
Daniel Chelsky, Cara Joyce, H. Jeremy Bockholt, Paul A. Rudnick, William H. Adams, Fiona McAllister, Justin W. Smock, Michael A. Newton, Jane S. Paulsen   +8 more
wiley   +1 more source

On Moments of Inverse Kumaraswamy Distribution Based on Progressive Type-II Censored Order Statistics

Journal of Statistical Theory and Applications (JSTA)
Daghistani et al. (Pak J Stat Oper Res 989–997, 2019) introduced and investigated the properties of the new inverse Kumaraswamy distribution. This distribution has numerous applications in various fields, including life testing, biology, and medicine ...
Areej M. AL-Zaydi
doaj   +1 more source

Mean squared error of empirical predictor

, 2004
The term ``empirical predictor'' refers to a two-stage predictor of a linear combination of fixed and random effects. In the first stage, a predictor is obtained but it involves unknown parameters; thus, in the second stage, the unknown parameters are ...
Das, Kalyan, Jiang, Jiming, Rao, J. N. K.   +2 more
core   +2 more sources