Results 91 to 100 of about 1,416,194 (310)

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Cancer cell‐intrinsic type 1 interferon: production, signaling, and outcomes within sex‐biased, female malignancies

Molecular Oncology, EarlyView.
The cell‐autonomous roles of interferon type 1 vary based on duration and intensity. While acute, robust signaling results in cancer cell cytotoxic effects, sustained, low‐level signaling is associated with tumor‐promoting effects. This review summarizes current research of IFN‐1 in cancer and within the clinical setting, with an emphasis on female ...
Ashlyn Conant, Nora Badiner, Sharon Asariah, Kiera McGivney, Vishwa Shah, Tise Suzuki, Yevgeniya J. Ioffe, Juli J. Unternaehrer   +7 more
wiley   +1 more source

Consensus Practice Guidelines for Conventional Transarterial Chemoembolization (cTACE) in the Treatment of Hepatocellular Carcinoma

Journal of Clinical Interventional Radiology ISVIR
This consensus guidelines document is a collaborative effort by a panel of interventional radiologists from India. It defines the criteria for selecting appropriate patients, outlines the standard techniques for performing conventional chemoembolization [
Anubhav Harish Khandelwal, Amar Mukund, Arun Gupta, Dayananda Lingegowda, Jagadeesh Singh, Madhu Prashanth, Naveen Kalra, Reddi Prasad Yadavali, Sanjeeva Prasad Kalva, Satheesh Ramamurthy, Shivanand Gamanagatti, Shuvro Roy Choudhury, Shyamkumar Nidugala Keshava, Surabhi Jajodia, Suyash Kulkarni, Jin Wook Chung, Sanjay Saran Baijal   +16 more
doaj   +1 more source

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Best practice portals in health promotion and disease prevention: approaches, definitions, and intervention evaluation criteria

Frontiers in Public Health
IntroductionThe evaluation of practices is a valuable source of evidence in the context of an evidence-based approach to public health. Best practice portals (BPPs) are promising tools for facilitating access to recommended programmes, monitoring and ...
Maria Piotrowicz, Małgorzata Gajewska, Katarzyna Lewtak, Katarzyna Lewtak, Ewa Urban, Anna Rutyna, Aneta Nitsch-Osuch   +6 more
doaj   +1 more source

Keeping Time: An Introduction to Archival Best Practices for Music LibrariansKeeping Time: An Introduction to Archival Best Practices for Music Librarians By Lisa Hooper and Donald C. Force . Middleton, Wis.: A-R Editions, 2014. Softcover. $50.00. ISBN 978-0-89579-786-5. [PDF]

, 2015
Adriana P. Cuervo
openalex   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source