Results 61 to 70 of about 6,295,741 (283)
Molecular Oncology, EarlyView.We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto +8 more
wiley +1 more source
Molecular Oncology, EarlyView.Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Next‐generation proteomics improves lung cancer risk prediction
Molecular Oncology, EarlyView.This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj +4 more
wiley +1 more source
Evaluation of integrated care: ensuring rigor, scaling up, scaling out
International Journal of Integrated Care, 2019 Health systems face significant challenges in moving towards integrated care. Despite long time policy pressures and the existence of best practice models at international level, integrated care frequently remains limited to pilot projects.
Oliver Groene
doaj +1 more source
DDI Best Practices: Technical Best Practices
, 2009 As presented at IASSIST 2009 ...
openaire +1 more source
Proposed best practice for projects that involve modelling and simulation [PDF]
, 2017 Modelling and simulation has been used in many ways when developing new treatments. To be useful and credible, it is generally agreed that modelling and simulation should be undertaken according to some kind of best practice.
Anisimov +8 more
core +1 more source
Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
Molecular Oncology, EarlyView.WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source
Putting women’s eyesight first
Community Eye Health Journal, 2016 Two-thirds of blindness and visual impairment occurs in women, and recent prevalence surveys in Vietnam and China show an imbalance in the coverage of services across some areas.
Damian Facciolo , Camille Neyhouser
doaj
Best practice for supporting students in the workplace. [PDF]
, 2018 We investigated the academic performance of distance-taught student Paramedics and the effect of workplace support measures offered by their employers. Using a combination of quantitative, qualitative and open text data, we identified factors important ...
Aiken, Fiona, MacQueen, Hilary
core