Results 51 to 60 of about 800,688 (313)

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Benzodiazepine prescribing patterns among Medicare providers, 2017 to 2023

Frontiers in Medicine
IntroductionTo determine whether benzodiazepine (BZD) prescriptions in older adults (>65) generally adhere to the Beers Criteria of the American Geriatrics Society, and whether the likelihood of prescribing an average of > 30 days per beneficiary ...
Olivia Silvernail, Alexis D. Ritvo, Bernard Silvernail, Peter R. Martin, Peter R. Martin   +4 more
doaj   +1 more source

Training cameroonian researchers on pragmatic knowledge translation trials: a workshop report

The Pan African Medical Journal, 2014
Limited health research capacity in one of the factors that prevents developing countries from attaining optimal health outcomes and achieving the Millennium Development Goals.
Lawrence Mbuagbaw, Lehana Thabane, Pierre Ongolo-Zogo   +2 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Ocean Best Practices Workshop II: Implementation.

, 2018
Presentation at 'Evolving and Sustaining Ocean Best Practices Workshop II, Intergovernmental Oceanographic Commission, Paris, France, 04-06 Dec 2018 ...
Pearlman, Jay
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Best Practices Tool-Kit: Gender Responsive Strategies [PDF]

, 2006
This Best Practices Tool-Kit aims to systematically identify empirical evidence regarding gender-responsive research, strategies, programs and practices.
Pettway, Coretta
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CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Best Practices and Known Limitations 6

, 2014
This design guide provides guidelines and best practices for customer deployments of IP Security (IPsec) direct encapsulation VPNs.
Best Practices Summary
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CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Streamlined Sales Tax Governing Board Section 328 Best Practices Matrix

, 2014
A “best practice ” has been approved by the Streamlined Sales Tax Governing Board (SSTGB) for each of the products, procedures, services, or transactions identified in the chart below pursuant to Section 335 of the Streamlined Sales and Use Tax Agreement
Practices Matrix, Section Best
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