Results 111 to 120 of about 6,428,588 (298)

Blocking the voltage‐gated sodium channel hNav1.5 as a novel pH‐dependent mechanism of action for tamoxifen

open access: yesFEBS Open Bio, EarlyView.
Patch‐clamp recordings revealed that tamoxifen inhibits voltage‐gated sodium channels, especially under acidic conditions, both common in metastatic cancer cells. These effects may explain certain antitumor properties of tamoxifen, highlighting a novel mechanism of action beyond its known endocrine effects.
Karl Josef Föhr   +5 more
wiley   +1 more source

Characterizing Stability Properties in Games with Strategic Substitutes [PDF]

open access: yes
In games with strategic substitutes (GSS), convergence of the best response dynamic starting from the inf (or sup) of the strategy space is equivalent to global stability (convergence of every adaptive dynamic to the same pure strategy Nash equilibrium).
Sunanda Roy, Tarun Sabarwal
core  

Teaching Python with team‐based learning: using cloud‐based notebooks for interactive coding education

open access: yesFEBS Open Bio, EarlyView.
This study presents a novel approach to teaching Python and bioinformatics using team‐based learning and cloud‐hosted notebooks. By integrating interactive coding into biomedical education, the method improves accessibility, student engagement, and confidence—especially for those without a computing background.
Nuno S. Osório, Leonardo D. Garma
wiley   +1 more source

Equilibrium Play and Best Response to (Stated) Beliefs in Constant Sum Games [PDF]

open access: yes
We report experimental results on one-shot two person 3x3 constant sum games played by non-economists without previous experience in the laboratory.
Pedro Rey-Biel
core  

Most autophagic cell death studies lack evidence of causality

open access: yesFEBS Open Bio, EarlyView.
Of 104 studies claiming autophagic cell death (ACD), only 13 demonstrated both causality and exclusion of apoptosis to confirm true ACD. Most studies relied on correlation‐level data or measured autophagy in isolation, revealing pervasive methodological shortcomings.
Ali Burak Özkaya, Yasmin Ghaseminejad
wiley   +1 more source

Rock-Paper-Scissors; A New and Elegant Proof [PDF]

open access: yes
I provide an elegant proof identifying the unique mixed Nash equilibrium of the Rock-Paper-Scissors game. The proof is based on intuition rather than elimination of cases.
A. van den Nouweland
core  

What are Some Best HR Practices in Response to Natural Disasters in Terms of Training and Communication? [PDF]

open access: yes, 2013
Today’s world is defined by, among other characteristics, borderless and unconventional threats, global challenges, and fast-paced change. HR has not been initially designed to organize or oversee crisis management.
Thomas, Desiree, Zhou, Cindy
core   +1 more source

Rethinking plastic waste: innovations in enzymatic breakdown of oil‐based polyesters and bioplastics

open access: yesFEBS Open Bio, EarlyView.
Plastic pollution remains a critical environmental challenge, and current mechanical and chemical recycling methods are insufficient to achieve a fully circular economy. This review highlights recent breakthroughs in the enzymatic depolymerization of both oil‐derived polyesters and bioplastics, including high‐throughput protein engineering, de novo ...
Elena Rosini   +2 more
wiley   +1 more source

Interplay between RNA‐protein interactions and RNA structures in gene regulation

open access: yesFEBS Open Bio, EarlyView.
Methodological advances in mapping transcriptome‐wide RNA‐protein interactions and RNA structures have started to uncover the potential of RNP conformations in gene regulation. Competing RNA–RNA, RNA‐protein and protein–protein interactions shape the compaction and function of RNPs throughout their lifetime and may provide novel therapeutic targets in ...
Jenni Rapakko   +2 more
wiley   +1 more source

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