Results 111 to 120 of about 17,303,475 (361)

Adverse prognosis gene expression patterns in metastatic castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
We aggregated a cohort of 1012 mCRPC tissue samples from 769 patients and investigated the association of gene expression‐based pathways with clinical outcomes. Loss of AR signaling, high proliferation, and a glycolytic phenotype were independently prognostic for poor outcomes, and an adverse transcriptional feature score incorporating these pathways ...
Marina N. Sharifi, Eric Feng, Nicholas R. Rydzewski, Amy K. Taylor, Jamie M. Sperger, Yue Shi, Kyle T. Helzer, Matthew L. Bootsma, Viridiana Carreno, Alex H. Chang, Luke A. Nunamaker, Grace C. Blitzer, Tianfu Andy Shang, Aishwarya Subramanian, Anders Bjartell, Andreas Josefsson, Pernilla Wikström, Emily Feng, Manish Kohli, Rendong Yang, Scott M. Dehm, Eric J. Small, Rahul Aggarwal, David A. Quigley, Joshua M. Lang, Shuang G. Zhao, Martin Sjöström   +26 more
wiley   +1 more source

Plasma lipidomic and metabolomic profiles in high‐grade glioma patients before and after 72‐h presurgery water‐only fasting

Molecular Oncology, EarlyView.
Presurgery 72‐h fasting in GB patients leads to adaptations of plasma lipids and polar metabolites. Fasting reduces lysophosphatidylcholines and increases free fatty acids, shifts triglycerides toward long‐chain TGs and increases branched‐chain amino acids, alpha aminobutyric acid, and uric acid.
Iris Divé, Lisa Hahnefeld, Katharina J. Wenger, Donat Kögel, Joachim Steinbach, Gerd Geisslinger, Michael W. Ronellenfitsch, Irmgard Tegeder   +7 more
wiley   +1 more source

Putting out the Cerro Grande fire: a case study in government crisis communication [PDF]

, 2003
In 2000, the U.S. National Park Service (NPS) initiated a prescribed burn, which went awry, prompting New Mexico's largest wildfire to date. This paper examines the NPS’s crisis response in an effort to determine its media response, how that response ...
Darmon, Keren, Romo, Lara
core  

Nash equilibria sets in mixed extended 2x3 games [PDF]

Computer Science Journal of Moldova, 2005
We describe the Nash equilibria set as an intersection of best response graphs. The problem of Nash equilibria set construction for \hbox{two-person} mixed extended 2x3 games is studied.
Valeriu Ungureanu, Ana Botnari
doaj  

Community People Preparedness and Response on Prevention and Control of COVID-19 Best Practice in Bangladesh

Asia Pacific Journal of Health Management, 2020
Purpose: The major objectives of the study were to assess the knowledge, attitude & practice (KAP) towards community preparedness and response on prevention of COVID-19 among the community people.
Dr.Bimal Chandra Das, Sahedul Islam Bhuiyan, A S M Wali Ullah, Muhammad Zahangir Alam, Gazi Golam Mostofa, Khondaker Zahirul Hasan, Sohel Sarwar, Reaz Uddin Chowdhury, Joya Paul, AKM Mahbubul Haque, Mohammad Shamsal Islam, Mohammed Alauddin   +11 more
doaj   +1 more source

Targeting the MDM2‐MDM4 interaction interface reveals an otherwise therapeutically active wild‐type p53 in colorectal cancer

Molecular Oncology, EarlyView.
This study investigates an alternative approach to reactivating the oncosuppressor p53 in cancer. A short peptide targeting the association of the two p53 inhibitors, MDM2 and MDM4, induces an otherwise therapeutically active p53 with unique features that promote cell death and potentially reduce toxicity towards proliferating nontumor cells.
Sonia Valentini, Giada Mele, Marika Attili, Maria Rita Assenza, Fulvio Saccoccia, Francesca Sardina, Cinzia Rinaldo, Roberto Massari, Nicola Tirelli, Alfredo Pontecorvi, Fabiola Moretti   +10 more
wiley   +1 more source

A general model of best response adaptation [PDF]

We develop a general model of best response adaptation in large populations for symmetric and asymmetric conflicts with role-switching. For special cases including the classical best response dynamics and the symmetrized best response dynamics we show ...
Ulrich Berger
core  

Two neuronal groups for NaCl with differential taste response properties and topographical distributions in the rat parabrachial nucleus

Physiological Reports, 2020
It is crucial for animals to discriminate between palatable (safe) and aversive (toxic) tastants. The mechanisms underlying neuronal discrimination of taste stimuli remain unclear.
Tatsuko Yokota, Nubuo Katakura, Takumi Morita, Tomoko Matsunaga, Katsunari Hiraba   +4 more
doaj   +1 more source

Imperfect best-response mechanisms [PDF]

arXiv, 2012
Best-response mechanisms (Nisan, Schapira, Valiant, Zohar, 2011) provide a unifying framework for studying various distributed protocols in which the participants are instructed to repeatedly best respond to each others' strategies. Two fundamental features of these mechanisms are convergence and incentive compatibility.
arxiv  

Thermal proteome profiling and proteome analysis using high‐definition mass spectrometry demonstrate modulation of cholesterol biosynthesis by next‐generation galeterone analog VNPP433‐3β in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Elevated level of cholesterol is positively correlated to prostate cancer development and disease severity. Cholesterol‐lowering drugs, such as statins, are demonstrated to inhibit prostate cancer. VNPP433‐3β interrupts multiple signaling and metabolic pathways, including cholesterol biosynthesis, AR‐mediated transcription of several oncogenes, mRNA 5′
Retheesh S. Thankan, Elizabeth Thomas, Mehari M. Weldemariam, Puranik Purushottamachar, Weiliang Huang, Maureen A. Kane, Yuji Zhang, Nicholas Ambulos, Bi‐Dar Wang, David Weber, Vincent C. O. Njar   +10 more
wiley   +1 more source