Aging Is a Key Driver for Adult Acute Myeloid Leukemia
Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley +1 more source
Molecular Design and Experimental Study of Deep Eutectic Solvents Extraction of Polydatin from <i>Polygonum cuspidatum</i>. [PDF]
Cai X +5 more
europepmc +1 more source
Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang +3 more
wiley +1 more source
Considerations for the Use of Brain Endurance Training in Elite Sport: A Narrative Review. [PDF]
Joseph SD +7 more
europepmc +1 more source
This systematic review synthesizes prognostic models for survival and recurrence in resected non‐small cell lung cancer. While many models demonstrate moderate to good discrimination, few are externally validated and reporting quality is variable, limiting clinical applicability and highlighting the need for robust, transparent model development ...
Evangeline Samuel +4 more
wiley +1 more source
Bet-hedging via Kelly betting in a limited environment leads to logistic growth in the Game of Fitness. [PDF]
Gulec F +3 more
europepmc +1 more source
Structural Determination of a Human IgE Epitope on Major Birch Allergen Bet v 1. [PDF]
O'Malley A +4 more
europepmc +1 more source
T-bet: biological functions, molecular mechanisms, and therapeutic applications: a systematic review. [PDF]
Yang X, Sun M, Tang X, Zhang X, Shen W.
europepmc +1 more source
Comparative Evaluation of Synthetic Zeolites for Radium and Barium Removal from Contaminated Water: From Ideal Solutions to Real Mine Water Matrix. [PDF]
Samolej K +3 more
europepmc +1 more source

