Results 71 to 80 of about 263,197 (302)
Stereoselective synthesis of allele-specific BET inhibitors [PDF]
, 2020 Developing stereoselective synthetic routes that are efficient and cost-effective allows easy access to biologically active molecules. Our previous syntheses of allele-selective bumped inhibitors of the Bromo and Extra-Terminal (BET) domain proteins ...
Testa, Andrea +5 more
core +3 more sources
Therapeutic Apheresis and Dialysis, EarlyView.ABSTRACT Background Patients with chronic kidney disease undergoing hemodialysis commonly experience reduced physical function, fatigue, poor sleep quality, and impaired health‐related quality of life. Intradialytic exercise has been proposed as a non‐pharmacological strategy to improve these outcomes.
Klebson da Silva Almeida +6 more
wiley +1 more source
, 2016 Pulmonary macrophages were isolated from naïve mice and stimulated with IFNγ/LPS in presence of I-BET-762 or vehicle for 12h. Expression of MCP-1 (A), KC (B), TNFα (C), IL27p28 (D), and IFNγ (E) were assessed by qPCR. Values are presented as mean ± SEM. *
Ming Yang (109148) +4 more
core +1 more source
Therapeutic Apheresis and Dialysis, EarlyView.ABSTRACT Introduction Peritoneal dialysis (PD) is an established home‐based kidney replacement therapy (KRT), but its uptake remains low in Japan. We evaluated whether individualized education in a dedicated outpatient clinic was associated with the initiation of PD.
Yasuko Ito +7 more
wiley +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Orbital: The Electronic Journal of Chemistry, 2017 This study reports the production of activated carbon (AC) from chemical activation with sodium hydroxide in pyrolysis temperature of 500 to 600 °C using alternative and renewable material, Buriti petiole.
Cristiane Freitas de Almeida +6 more
doaj +1 more source
Stability of the Bet v 1 cross-reactive allergens Api g 1 and Dau c 1 : a biophysical approach [PDF]
, 2009 The allergen Bet v 1 is known as the primary sensitizer for birch pollen-related food allergy and is responsible for IgE cross-reactivity to pathogenesis-related 10 (PR-10) proteins from, in particular, fruits from the Rosaceae and vegetables from the ...
Bollen, M.A.
core
Recombinant MCP-1 administration overcomes I-BET-762-mediated suppression of AHR and inflammation.
, 2016 Mice were administered IFNγ/LPS/rMCP-1 i.t at 0h. Some groups were treated with I-BET-762 i.v 1h before and 4h after IFNγ/LPS/rMCP-1 exposure. Endpoints were assessed at 12h.
Ming Yang (109148) +4 more
core +1 more source
Pre-Decision Side-Bet Sequences [PDF]
, 2017 Risk-averse Expected Utility (EU) decision makers with wealth-dependent utility functions may find themselves indifferent between accepting and rejecting an indivisible risky prospect.
Peel, David Alan, Kaivanto, Kim Kaleva
core +3 more sources
FEBS Letters, EarlyView.Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley +1 more source