Results 141 to 150 of about 125,959 (267)

Aging Is a Key Driver for Adult Acute Myeloid Leukemia

Aging and Cancer, EarlyView.
Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley   +1 more source

Resistance to the KRASG12D Inhibitor MRTX1133 Is Associated with Increased Sensitivity to BET Inhibition. [PDF]

Mol Cancer Ther
Principe DR, Becker JH, Metropulos AE, Marinelarena AM, Pham TD, Aissa AF, Munshi HG.   +6 more
europepmc   +1 more source

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

Edible Natural Deep Eutectic Solvents (NADESs)-Based Polyphenolic Extracts: An Eco-Sustainable Alternative for Grape Pomace Valorization. [PDF]

Molecules
Roselli V, Leuci R, Paparella M, Pugliese G, Luz C, Cimbalo A, Manyes L, Tarricone L, Tufarelli V, Gambacorta L, Meca G, Piemontese L.   +11 more
europepmc   +1 more source

Risk Prediction Models for Recurrence After Curative Treatment of Early‐Stage or Locally Advanced Lung Cancer: A Systematic Review

Aging and Cancer, EarlyView.
This systematic review synthesizes prognostic models for survival and recurrence in resected non‐small cell lung cancer. While many models demonstrate moderate to good discrimination, few are externally validated and reporting quality is variable, limiting clinical applicability and highlighting the need for robust, transparent model development ...
Evangeline Samuel, S. Tissera, E. Paul, J. Zalcberg, R. G. Stirling   +4 more
wiley   +1 more source

Electrochemical Impedance Spectroscopy as a Tool To Investigate the Electrochemical Behavior of Beetroot and Spinach Extracts. [PDF]

ACS Omega
de Oliveira FG, Barcellos TMA, Ribeiro Weberling TL, Alvares TS, Melo RS.   +4 more
europepmc   +1 more source

Intelligent Tutoring Systems for Adult Learning in STEM Disciplines

New Directions for Adult and Continuing Education, EarlyView.
ABSTRACT Intelligent tutoring systems (ITS) are reshaping adult learning in STEM by providing adaptive, data‐driven instruction across classrooms, workplaces, and informal environments. In the context of ITS, this article compares generative AI, which creates personalized explanations and practice materials, with explainable AI, which focuses on ...
Jill Zarestky, Amanda R. Lager Gleason
wiley   +1 more source

Age-associated B cells, key players in autoimmune pathogenesis. [PDF]

Immun Ageing
Hassani SS, Ekrani ST, Rajabinejad M, Faraj TA, Rezaiemanesh A, Esmaeili SA.   +5 more
europepmc   +1 more source

Artificial Intelligence and Mental Well‐Being in Adult Education: Implications for Practice and Professional Responsibility

New Directions for Adult and Continuing Education, EarlyView.
ABSTRACT Mental well‐being is central to adult learner success, yet many adult education institutions lack capacity to provide timely and accessible support. This article examines how artificial intelligence (AI) can strengthen mental health–adjacent supports in adult and continuing higher education, with attention to professional practice and ...
Adam L. McClain, Thomas Wade
wiley   +1 more source

Effects of unilateral and bilateral eccentric training on lower limb maximal strength, jump, and sprint performance in trained adolescent male basketball players: a randomized controlled trial. [PDF]

BMC Sports Sci Med Rehabil
Wu B, Hu J, Hu S, Liu Z, Yin M, Xu K, Tao M, Yue L, Liu H, Chen A, Song Z.   +10 more
europepmc   +1 more source