Results 171 to 180 of about 7,346,118 (311)

PROTAC-induced BET protein degradation as a therapy for castration-resistant prostate cancer

Proceedings of the National Academy of Sciences of the United States of America, 2016
Kanak Raina, Jing Lu, Y. Qian, M. Altieri, Deborah A Gordon, AnnMarie K. Rossi, Jing Wang, Xin Chen, Han-Qing Dong, Kam W. Siu, J. Winkler, A. Crew, C. Crews, K. Coleman   +13 more
semanticscholar   +1 more source

Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids

FEBS Open Bio, EarlyView.
Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão, Diogo M. Engrácia, Graça Soveral, Filipa Mendes   +3 more
wiley   +1 more source

Pyrolysis of Camellia oleifera Shell at Intermediate Temperatures, and Prediction of Bio-oil Component Levels by Mathematical Modeling

BioResources
Camellia oleifera shell was pyrolysed at 300 to 750 °C to investigate biochar and bio-oil yields under different conditions, and the relationships between pyrolysis temperature and the product yields were established.
Rongqu Bei, Wenrui Xie, Xuefei Gan, Yuefang Chen, Zhengbin He   +4 more
doaj  

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Epigenetic Rewiring and Context-Dependent Therapeutic Vulnerabilities in Myeloproliferative Neoplasms. [PDF]

Hematol Oncol
Abdelgawwad El-Sehrawy AAM, Al-Khreisat MJ, Kubaev A, Rajapov A, Ismael SH, Alhasso B, Kaur I, Bainsal N.   +7 more
europepmc   +1 more source

Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface

FEBS Open Bio, EarlyView.
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana, Avigail Yariv, Tal Oppenheim, Hadar Amartely, Dana Reichmann, Oded Livnah   +5 more
wiley   +1 more source

The Developmental and Functional Implications of Age-Associated B Cells (ABCs) Across Tissue Microenvironments. [PDF]

Immunol Rev
Francis RL, Weinstein JS.
europepmc   +1 more source

A new flow chip in combination with multiphoton microscopy as a protocol for longitudinal 3D imaging of tissue calcification under shear stress

FEBS Open Bio, EarlyView.
Miniaturized flow chip platform enabling continuous perfusion and longitudinal multiphoton 3D imaging of vascular smooth muscle cell constructs under physiological flow. Brightfield imaging guides region selection, while CellTracker Green and mRuby‐labeled fetuin‐A visualize cells and mineral deposition, respectively. Magnesium supplementation markedly
Vytautas Kučikas, Aaron D. Morgan, Ignas Čiurlionis, Christian Böhm, Stefan Jockenhövel, Willi Jahnen‐Dechent, Marc A. M. J. van Zandvoort   +6 more
wiley   +1 more source

¹H HR-MAS NMR Metabolomics in Combination With Transcriptomic Correlation Provides New Insights Into Metabolic Heterogeneity Across Breast Cancer Immunohistochemical Subtypes. [PDF]

NMR Biomed
Garcia-Bocanegra I, Urbano-Gamez JD, Perez-Cardona A, Barrios L, Somoza-Ramírez MI, Vicioso L, Pardo-Susacasa E, Diaz-Cordoba G, Acebal-Blanco MM, Sendra-Portero F, Garcia-Martin ML.   +10 more
europepmc   +1 more source