Results 41 to 50 of about 7,346,118 (311)
Nature Communications, 2021 BRD4, a Bromodomain and Extraterminal (BET) protein family member, is a promising anti-cancer drug target. However, resistance to BET inhibitors targeting BRD4 is common in solid tumors.
Wen-Yu Wang +14 more
semanticscholar +1 more source
Journal of Animal Science and Biotechnology, 2022 Background Sperm quality evaluation is the logical first step in increasing field fertility. Spermatozoa contain cytoplasmic organelles and biomolecules known as sperm-intrinsic factors, which play key roles in sperm maturation, sperm-oocyte fusion, and ...
Won-Ki Pang +5 more
doaj +1 more source
Synthesis and characterization of nano Fe2CuAl2O7 as a reusable catalyst for Biginelli reaction [PDF]
Journal of the Serbian Chemical SocietyIn this research, the novel mixed metal oxide nanoparticles (NPs) Fe2CuAl2O7 were synthesized by applying sol-gel auto-combustion method. The Fe2CuAl2O7 NPs were identified by XRD, FT-IR, Mapping and EDS.
Keshtiban Marzieh M. +2 more
doaj +1 more source
المقاربة الأسلوبية بين صرامة المنهج ورهان المعنى (رؤى ومقاصد)
التراث الأدبي, 2023 This study is interested in the research of stylistic approach basics that seeks to interprete the literary discourse according to the linguistic levels searching on signification which uncover the letters, and visions hidden inside the text, as well ...
Prof. Dr. Abdessamiaa Mouffok
doaj +1 more source
Cell Reports, 2021 SUMMARY The transcription factors T-bet and Eomesodermin (Eomes) regulate CD8 T cell exhaustion through undefined mechanisms. Here, we show that the subcellular localization of T-bet and Eomes dictate their regulatory activity in exhausted T cells (TEXs).
Laura M. McLane +17 more
semanticscholar +1 more source
IL-21 drives expansion and plasma cell differentiation of autoreactive CD11chiT-bet+ B cells in SLE
Nature Communications, 2018 Although the aetiology of systemic lupus erythematosus (SLE) is unclear, dysregulated B cell responses have been implicated. Here we show that an unusual CD11chiT-bet+ B cell subset, with a unique expression profile including chemokine receptors ...
Shu Wang +30 more
semanticscholar +1 more source
Sequential actions of EOMES and T-BET promote stepwise maturation of natural killer cells
Nature Communications, 2021 EOMES and T-BET are related T-box transcription factors that control natural killer (NK) cell development. Here we demonstrate that EOMES and T-BET regulate largely distinct gene sets during this process.
Jiang Zhang +19 more
semanticscholar +1 more source
A Comprehensive Review of BET Protein Biochemistry, Physiology, and Pathological Roles
Frontiers in Pharmacology, 2022 Epigenetic modifications, specifically acetylation of histone plays a decisive role in gene regulation and transcription of normal cellular mechanisms and pathological conditions.
Hafiz Akbar Ali +5 more
semanticscholar +1 more source
Sesame-residue biochar as a sorbent for salinity ions: capacity, isotherm, and kinetics [PDF]
محیط زیست و مهندسی آبWater scarcity is a reality in arid and semi-arid regions, leading to competition for limited water resources among agricultural, domestic, and industrial needs. In this study, sesame seed residue (Sr) adsorbents and biochar produced at 400 (B1), 500 (B2)
Mohammadreza Nouri-Shamsi +3 more
doaj +1 more source
The Functions of BET Proteins in Gene Transcription of Biology and Diseases
Frontiers in Molecular Biosciences, 2021 The BET (bromodomain and extra-terminal domain) family proteins, consisting of BRD2, BRD3, BRD4, and testis-specific BRDT, are widely acknowledged as major transcriptional regulators in biology.
K. Cheung, Claudia Kim, Ming-Ming Zhou
semanticscholar +1 more source