Results 11 to 20 of about 7,346,118 (311)
BET Bromodomain Inhibitors: Novel Design Strategies and Therapeutic Applications
Molecules, 2023 The mammalian bromodomain and extra-terminal domain (BET) family of proteins consists of four conserved members (Brd2, Brd3, Brd4, and Brdt) that regulate numerous cancer-related and immunity-associated genes.
K. To +3 more
semanticscholar +1 more source
Achieving clinical success with BET inhibitors as anti-cancer agents
British Journal of Cancer, 2021 The transcriptional upregulation of oncogenes is a driving force behind the progression of many tumours. However, until a decade ago, the concept of ‘switching off’ these oncogenic pathways represented a formidable challenge.
T. Shorstova +2 more
semanticscholar +1 more source
Exploration of Targeted Anti-tumor Therapy, 2021 Aim: Bromodomain and extra-terminal domain (BET) proteins are epigenetic readers that play a fundamental role in transcription regulation. Preclinical and early clinical evidence sustain BET targeting as an anti-cancer approach.
Chiara Tarantelli +14 more
doaj +1 more source
Vocabulary of the alchik game of the Kalmyks (ethnolinguistic aspect)
Nomadic Civilization: Historical Research, 2022 Alchiki (dice) game is an ancient folk game of nomadic peoples. It was known throughout Eurasia from the Atlantic to the Pacific Ocean, from the Kola Peninsula to Asia Minor.
M. U. Monraev
doaj +1 more source
The BET family in immunity and disease
Signal Transduction and Targeted Therapy, 2021 Innate immunity serves as the rapid and first-line defense against invading pathogens, and this process can be regulated at various levels, including epigenetic mechanisms.
Nian Wang, Runliu Wu, D. Tang, R. Kang
semanticscholar +1 more source
To Bet, or Not to Bet: That Is the Question of SEF Spikes [PDF]
Neuron, 2012 The ability of animals to monitor their own cognitive processes is called metacognition. In this issue of Neuron, Middlebrooks and Sommer (2012) show that single-unit activity of SEF neurons exhibit a metacognitive signal while monkeys perform a postdecision wagering task.
Miyamoto, Kentaro +2 more
openaire +2 more sources
THE INFLUENCE OF THE COVID 19 ON THE BET AND WIG20 INDICES. COMPARATIVE ASPECTS [PDF]
Oradea Journal of Business and Economics, 2021 The aim of the paper is to assess the effects of the coronavirus pandemic (COVID – 19) on two stock market indices: BET index for Bucharest Stock Exchange and WIG20 index for Warsaw Stock Exchange.
Catalin Florin Barnut
doaj +1 more source
T-BET and EOMES sustain mature human NK cell identity and antitumor function
Journal of Clinical Investigation, 2023 Since the T-box transcription factors (TFs) T-BET and EOMES are necessary for initiation of NK cell development, their ongoing requirement for mature NK cell homeostasis, function, and molecular programming remains unclear.
Pamela Wong +27 more
semanticscholar +1 more source
Markov Switching Model for Financial Time Series [PDF]
Ovidius University Annals: Economic Sciences Series, 2021 Modeling financial time series is an important step for its forecast and risk evaluation when financial assets are involved. In this context, this article presents a Markov Switching Model for BET series recorded during the period Oct-2000 - Sept-2014 ...
Alina Barbulescu +1 more
doaj
Selective targeting of BD1 and BD2 of the BET proteins in cancer and immuno-inflammation
Science, 2020 Bromodomain inhibitors revisited Bromodomain and extraterminal domain (BET) proteins contribute to the pathogenesis of cancer and immune diseases through their effects on transcriptional regulation. BET proteins contain two nearly identical bromodomains,
O. Gilan +36 more
semanticscholar +1 more source