Results 61 to 70 of about 215,969 (313)
Optimization of sperm RNA processing for developmental research
Scientific Reports, 2020 Recent studies have demonstrated the significance of sperm RNA function as a transporter of important information directing the course of life. To determine the message contained in sperm RNA, it is necessary to optimize transcriptomic research tools ...
Won-Ki Pang +5 more
doaj +1 more source
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
I-BET-762 administration suppresses inflammatory lung cytokines in RSV-induced exacerbation.
, 2016 mRNA levels were assessed by qPCR (A), and protein levels were validated by ELISA (B) on day 24. n = 6–8 mice/group, data presented as mean ± SEM. *Designates significant differences to PBS-treated controls (**P#Designates significant differences from ...
Ming Yang (109148) +4 more
core +1 more source
Stereoselective synthesis of allele-specific BET inhibitors [PDF]
, 2020 Developing stereoselective synthetic routes that are efficient and cost-effective allows easy access to biologically active molecules. Our previous syntheses of allele-selective bumped inhibitors of the Bromo and Extra-Terminal (BET) domain proteins ...
Testa, Andrea +5 more
core +1 more source
The human gut microbiome across the life course
FEBS Letters, EarlyView.Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero +4 more
wiley +1 more source
Orbital: The Electronic Journal of Chemistry, 2017 This study reports the production of activated carbon (AC) from chemical activation with sodium hydroxide in pyrolysis temperature of 500 to 600 °C using alternative and renewable material, Buriti petiole.
Cristiane Freitas de Almeida +6 more
doaj +1 more source
, 2019 9th Bet Debora Conference "Jewish Women: Being Present, Bringing Change" covered following topics: contemporary women’s perspectives on Jewish tradition; advocacy for other minority groups: activism against antisemitism, antiziganism, racism, and ...
core
Bet-hedging strategies in expanding populations
, 2019 In ecology, species can mitigate their extinction risks in uncertain environments by diversifying individual phenotypes. This observation is quantified by the theory of bet-hedging, which provides a reason for the degree of phenotypic diversity observed ...
Miguel A Muñoz +9 more
core +2 more sources
Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations
FEBS Letters, EarlyView.The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas +6 more
wiley +1 more source
FEBS Letters, EarlyView.We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace +6 more
wiley +1 more source