Results 101 to 110 of about 692,791 (244)
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
The Beta-Blocker Heart Attack Trial
, 1981 The National Heart, Lung, and Blood Institute has taken the unusual step of prematurely ending one of its major clinical trials, the Beta-Blocker Heart Attack Trial (BHAT), on the advice of its Policy and Data Monitoring Board.
core
Ocular surface changes in glaucomatous patients treated with and without preservatives beta-blockers
, 2014 To determine whether there were ocular surface changes in glaucomatous patients treated with preservatives beta-blockers who switched to preservative-free beta-blockers. METHODS: This was a prospective, longitudinal, open-labeled study.
Motolese, Ilaria +15 more
core +1 more source
Beta-adrenoblockers: treatment principles in international clinical guidelines
Кардиоваскулярная терапия и профилактика, 2005 The article contains data on beta-blocker efficacy in cardiology – the results of large, randomized clinical trials, and evidence-based clinical guidelines on beta-blocker therapy.
S. Yu. Martsevich
doaj
Molecular Oncology, EarlyView.Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski +12 more
wiley +1 more source
IntroductionWhile beta-blockers are considered the cornerstone of treatment for heart failure with reduced ejection fraction, the same may not apply to patients with heart failure with preserved ejection fraction (HFpEF).
Vichithranie Madurasinghe (3438182) +11 more
core +1 more source
Beta-Blocker Use and Outcomes Among Hospitalized Heart Failure Patients
, 2006 OBJECTIVES The purpose of this study was to determine the effect of beta-blocker therapy on outcomes of hospitalized heart failure (HF) patients enrolled in the Evaluation Study of Congestive Heart Failure and Pulmonary Artery Catheterization (ESCAPE ...
Young, James +6 more
core +1 more source
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
, 2016 Michael Heffernan Division of Cardiology, Oakville Trafalgar Memorial Hospital, Oakville, ON, Canada Abstract: A comprehensive analysis of beta-blocker utilization and other guideline-recommended therapies for the treatment of chronic heart failure in a
Heffernan M
core