Results 31 to 40 of about 28,193 (228)

Coupling of alpha(1)-Adrenoceptors to ERK1/2 in the Human Prostate [PDF]

, 2011
Introduction: alpha(1)-Adrenoceptors are considered critical for the regulation of prostatic smooth muscle tone. However, previous studies suggested further alpha(1)-adrenoceptor functions besides contraction.
Anglin IE, Boris Schlenker, Chang L, Chon JK, Christ GJ, Christian G. Stief, Christian Gratzke, Erdogru T, Frank Strittmatter, Glassman DT, Golomb E, Johanna Göttinger, Kanagawa K, Karl-Erik Andersson, Kyprianou N, Kyprianou N, Kyprianou N, Lucia MS, Luthin GR, Marinese D, Maroni PD, Martin Hennenberg, McCubrey JA, McVary KT, Michel MC, Oliver Reich, Petter Hedlund, Ricarda M. Bauer, Roehrborn CG, Roehrborn CG, Royuela M, Royuela M, Schilit S, Schwinn DA, Shimada K, Srinivasan D, Turkeri LN, Xiao L, Zhang H, Zhang Z   +39 more
core   +1 more source

Cloning, expression, and chromosomal localization of beta-adrenergic receptor kinase 2. A new member of the receptor kinase family

Journal of Biological Chemistry, 1991
The beta-adrenergic receptor kinase (beta ARK) specifically phosphorylates the agonist-occupied form of the beta-adrenergic and related G protein-coupled receptors. Structural features of this enzyme have been elucidated recently by the isolation of a cDNA that encodes bovine beta ARK.
J L, Benovic, J J, Onorato, J L, Arriza, W C, Stone, M, Lohse, N A, Jenkins, D J, Gilbert, N G, Copeland, M G, Caron, R J, Lefkowitz   +9 more
openaire   +2 more sources

Functional desensitization of the isolated beta-adrenergic receptor by the beta-adrenergic receptor kinase: potential role of an analog of the retinal protein arrestin (48-kDa protein). [PDF]

Proceedings of the National Academy of Sciences, 1987
The beta-adrenergic receptor kinase is an enzyme, possibly analogous to rhodopsin kinase, that multiply phosphorylates the beta-adrenergic receptor only when it is occupied by stimulatory agonists. Since this kinase may play an important role in mediating the process of homologous, or agonist-specific, desensitization, we investigated the functional ...
Benovic, JL, Kühn, H, Weyand, I, Codina, J, Caron, MG, Lefkowitz, RJ   +5 more
openaire   +2 more sources

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Critical Roles of STAT3 in β-Adrenergic Functions in the Heart [PDF]

, 2016
BACKGROUND: β-Adrenergic receptors (βARs) play paradoxical roles in the heart. On one hand, βARs augment cardiac performance to fulfill the physiological demands, but on the other hand, prolonged activations of βARs exert deleterious effects that ...
Chen, Biyi, Chen, Hanying, Fu, Xin-Yuan, Huang, Xin-Yun, Li, Baiyan, Li, Deqiang, Li, Xie, Liu, Ying, Qu, Xiuxia, Rubart, Michael, Shou, Weinian, Snyder, Marylynn, Song, Long-Sheng, Tang, Yue, Wang, Meijing, Yin, Ni, Zhan, Li, Zhang, J. Jillian, Zhang, Wenjun, Zhu, Wuqiang   +19 more
core   +1 more source

Microenvironmental Reprogramming by 3D Anisotropic Cardiac Extracellular Matrix Induces Nuclear Remodeling and Epigenetic Maturation of Chemically Induced Cardiomyocytes

Advanced Functional Materials, EarlyView.
A 3D anisotropic hydrogel derived from heart extracellular matrix guides cytoskeletal alignment and nuclear remodeling in reprogrammed cardiomyocyte‐like cells. This study reveals how matrix alignment modulates nuclear envelope dynamics and chromatin state, triggering transcriptional and functional maturation.
Seung Ju Seo, Mi Jeong Lee, Hyun Wook Kang, Seonhee Byeon, Soo‐Kyoung Choi, Nakwon Choi, Seung‐Woo Cho, Yoonhee Jin   +7 more
wiley   +1 more source

Natural Products Inspired Scaffold Diversification Leads to Unnatural Molecular Warhead and Covalent Strategy to Modulating Protein Function through Electrophilic Bromine Transfer

Advanced Science, EarlyView.
We report a new thiolate‐reactive α,α‐gem‐dibromo lactam warhead that activates transcription factor Nrf2 and demonstrates anti‐inflammatory activities, which have implications in cancer, neurodegeneration, and cardiovascular diseases. RNA‐seq illuminated detailed transcriptional profiles, and chemical reactions with cysteine‐containing compounds ...
Beau R. Brummel, Sofia Kokkaliari, Qiwen Gao, Jinjing Chen, Larissa Costa de Almeida, Srinivasarao Tenneti, Derek A. Leas, Eli Levit, Lewis S. Alexander, Khalil A. Abboud, Pingrong Wei, Michael D. Cameron, James R. Rocca, Ranjala Ratnayake, Donna D. Zhang, Hendrik Luesch, Robert W. Huigens III   +16 more
wiley   +1 more source

Altered excitation-contraction coupling in human chronic atrial fibrillation [PDF]

, 2012
This review focuses on the (mal)adaptive processes in atrial excitation-contraction coupling occurring in patients with chronic atrial fibrillation. Cellular remodeling includes shortening of the atrial action potential duration and effective refractory ...
Grandi, E., Pandit, S.V., Workman, A.J.
core   +1 more source

A beta-adrenergic receptor kinase-like enzyme is involved in olfactory signal termination. [PDF]

Proceedings of the National Academy of Sciences, 1993
We have previously shown that second-messenger-dependent kinases (cAMP-dependent kinase, protein kinase C) in the olfactory system are essential in terminating second-messenger signaling in response to odorants. We now document that subtype 2 of the beta-adrenergic receptor kinase (beta ARK) is also involved in this process.
Schleicher, S, Boekhoff, I, Arriza, J, Lefkowitz, RJ, Breer, H   +4 more
openaire   +2 more sources

β‐Adrenergic Signaling Promotes Anti‐Tumor Immunity in TP53‐mutant Oral Squamous Cell Carcinoma

Advanced Science, EarlyView.
β‐adrenergic stimulation enhances anti‐tumor immunity in TP53‐deficient oral squamous cell carcinoma by inducing tumor‐derived secretion of CXCL10, which attracts and activates cytotoxic CD8+ T cells. The findings demonstrate that β‐adrenergic signaling alters tumor–immune interactions via CXCL10‐mediated paracrine activation, revealing a neuro‐immune ...
Frederico O. Gleber‐Netto, Deborah Silverman, Tongxin Xie, Shamima Akhter, Nicole R. Vaughn, Adewale Adebayo, Kala Chand Debnath, Shorook Naara, Shajedul Islam, Erik Knutsen, Emily Lorin Ashkin, Simone Anfossi, Sara Leahey, Patrick Hwu, Sebastien Talbot, Erica K Sloan, Robert Saddawi‐Konefka, Roberto Rangel, Jeffrey N. Myers, George A. Calin, Moran Amit   +20 more
wiley   +1 more source