Results 71 to 80 of about 2,017,300 (180)
Innovations in Obesity Treatment: Beyond Adipose Tissue Dysfunction
Obesity Reviews, EarlyView.Obesity drives chronic inflammation, insulin resistance, type 2 diabetes, and cancer development through adipocyte dysfunction. Addressing this multisystemic disorder requires integrated strategies beyond diet and exercise, such as thermogenesis activation via menthol or capsinoids and appetite control through GLP‐1/GIP agonists and neuromodulation to ...
Jesica Martínez‐Godfrey +7 more
wiley +1 more source
Topical administration of adrenergic receptor pharmaceutics and nerve growth factor
, 2010 Jena J SteinleDepartments of Ophthalmology and Anatomy and Neurobiology, Hamilton Eye Institute, University of Tennessee Health Science Center, Memphis, TN 38163, USAAbstract: Topical application of nerve growth factor (NGF) and adrenergic receptor ...
Jena J Steinle
core
, 2008 Homologous desensitization of beta(2)-adrenergic and other G-protein-coupled receptors is a two-step process. After phosphorylation of agonist-occupied receptors by G-protein-coupled receptor kinases, they bind beta-arrestins, which triggers ...
Al-Sabah, S. +5 more
core +1 more source
Ion Channel Dysfunction and Therapeutic Targeting in Salivary Gland Disorders
Oral Diseases, EarlyView.ABSTRACT Objective Salivary gland hypofunction and xerostomia represent major clinical complications of radiation therapy, autoimmune disorders such as Sjögren's disease, and inherited epithelial ion transport defects. This review integrates current knowledge on ion channel dysfunction as a central mechanistic driver of salivary gland pathology and ...
Tarek Mohamed Abd El‐Aziz +6 more
wiley +1 more source
Impact of systemic diseases on periodontal remodeling: Mechanisms, mediators, and clinical relevance
Periodontology 2000, EarlyView.Abstract Background Periodontal remodeling is a continuous, adaptive process essential for maintaining the structural and functional integrity of periodontal tissues. While external factors such as bacterial biofilm, excessive forces, and poor oral hygiene are recognized triggers of periodontal pathologies, they do not fully explain their persistent ...
Michael Wolf +7 more
wiley +1 more source
Novel insights in β-adrenergic receptor signaling
, 2018 The adrenergic receptors (ARs) are G-protein-coupled receptors that in response to stimuli activate several intracellular signaling regulating key biologic functions and affecting several pathological conditions, mainly cardiovascular diseases (CV ...
Sorriento D., Iaccarino G.
core +1 more source
Die Funktion der Helix 8 für die Regulation des Bradykinin B2 Rezeptors [PDF]
, 2012 Upon activation the human bradykinin B2 receptor (B2R) acts as guanine nucleotide exchange factor for the G proteins Gq/11 and Gi. Thereafter, it gets phosphorylated by G protein-coupled receptor kinases (GRKs) and recruits beta-arrestins, which block ...
Feierler, Jens
core +1 more source
Understanding extracellular vesicles in antiaging
Periodontology 2000, EarlyView.Abstract Background Aging is a multifactorial process marked by gradual cellular dysregulation, regulated by hallmarks, including genomic instability, mitochondrial dysregulation, and chronic inflammation. Extracellular vesicles (EVs), especially exosomes, have emerged as pivotal mediators of cell‐to‐cell communication with potential roles in both ...
Paras Ahmad +3 more
wiley +1 more source
Experimental Physiology, EarlyView.Abstract Cold‐water immersion (CWI) is among the most widely used post‐exercise recovery modalities in elite sport and clinical rehabilitation, yet a fundamental paradox now emerges from the evidence: the same protocols that accelerate parasympathetic reactivation and reduce perceived muscle soreness also suppress the molecular and cellular machinery ...
Jose Francisco Tornero‐Aguilera +8 more
wiley +1 more source
The Journal of Physiology, EarlyView.Abstract figure legend The calcium‐activated chloride (ClCa) channel TMEM16A (also known as ANO1) plays critical roles in ion transport, neurotransmission and smooth muscle contraction. Dysregulation of TMEM16A channel activity contributes to the development and progression of various diseases.
Hisao Yamamura +4 more
wiley +1 more source