Results 111 to 120 of about 3,854,141 (349)

Heart rate variability and target organ damage in hypertensive patients [PDF]

, 2012
Background: We evaluated the association between linear standard Heart Rate Variability (HRV) measures and vascular, renal and cardiac target organ damage (TOD).
2003 European Society of Hypertension, A Garcia-Garcia, A Kluttig, A Musialik-Lydka, A Shehab, AI Vinik, AL Goldberger, AS Levey, B Dahlof, D Sahn, DH O'Leary, DJ Brotman, DW Kitzman, EB Schroeder, Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults, G de Simone, G Ferrari, G Iaccarino, G Lembo, G Mancia, G Martini, G Parati, GN Arbolishvili, JF Thayer, K Jensen-Urstad, K Oikawa, KH Tseng, L Pecchia, L Pecchia, LE Chambless, Leandro Pecchia, LM Ueno, Lomb, M Hollander, M Malik, M Zabalgoitia, MW Lorenz, N De Luca, N de Luca, Nicola De Luca, P Alter, P Chandra, P Hamilton, P Melillo, P Melillo, P Melillo, Paolo Melillo, R Izzo, Raffaele Izzo, RB Devereux, RB Devereux, RF Berntsen, RM Lang, S Kodituwakku, S Yusuf, U Rajendra Acharya, Z Bajko   +56 more
core   +4 more sources

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Impact of Beta‐Blocker Initiation Timing on Mortality Risk in Patients With Diabetes Mellitus Undergoing Noncardiac Surgery: A Nationwide Population‐Based Cohort Study

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2017
BackgroundRelevant clinical studies have been small and have not convincingly demonstrated whether the perioperative initiation of beta‐blockers should be considered in patients with diabetes mellitus undergoing noncardiac surgery.
Ray‐Jade Chen, Hsi Chu, Lung‐Wen Tsai   +2 more
doaj   +1 more source

Management of migraine [PDF]

, 1999
Migraine is a complex neurovascular disease characterised by episodic attacks of severe headache accompanied by autonomic and neurological symptoms. Two types of migraine have been identified: (1) common migraine, or migraine without aura, occurring in ...
Farrugia, Isabelle
core  

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

The Anxious Musician: Coping Strategies Used to Combat Music Performance Anxiety [PDF]

, 2019
Music Performance Anxiety, or MPA, affects over 20% of musicians, regardless of age, experience, or nationality. MPA is a form of social anxiety that causes the performer great distress before and during a performance experience, often causing the ...
Lockhart, Abigail
core   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Effects of sacubitril/valsartan in the PARADIGM-HF Trial (Prospective Comparison of ARNI with ACEI to Determine Impact on Global Mortality and Morbidity in Heart Failure) according to background therapy [PDF]

, 2016
Background—In the PARADIGM-HF trial (Prospective Comparison of ARNI with ACEI to Determine Impact on Global Mortality and Morbidity in Heart Failure), the angiotensin receptor neprilysin inhibitor sacubitril/valsartan was more effective than the ...
Gong, Jianjian, Jhund, Pardeep S., Lefkowitz, Martin P., McMurray, John J.V., Okumura, Naoki, Packer, Milton, Rizkala, Adel R., Rouleau, Jean L., Shi, Victor C., Solomon, Scott D., Swedberg, Karl, Zile, Michael R.   +11 more
core   +2 more sources

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Effects of renin-angiotensin system inhibitor and beta-blocker use on mortality in older patients with heart failure with reduced ejection fraction in Japan

Frontiers in Cardiovascular Medicine
IntroductionGuideline-directed medical therapy with renin-angiotensin system (RAS) inhibitors and beta-blockers has improved the survival of patients with heart failure (HF) and reduced left ventricular ejection fraction (HFrEF).
Kei Kawada, Kei Kawada, Tomoaki Ishida, Hitoshi Fukuda, Yuki Hyohdoh, Toru Kubo, Tomoyuki Hamada, Yuichi Baba, Toshinobu Hayashi, Fuka Aizawa, Fuka Aizawa, Kenta Yagi, Kenta Yagi, Yuki Izawa-Ishizawa, Yuki Izawa-Ishizawa, Takahiro Niimura, Takahiro Niimura, Shinji Abe, Mitsuhiro Goda, Mitsuhiro Goda, Hiroaki Kitaoka, Keisuke Ishizawa, Keisuke Ishizawa, Keisuke Ishizawa   +23 more
doaj   +1 more source