Results 181 to 190 of about 187,919 (323)

DDX3X induces mesenchymal transition of endothelial cells by disrupting BMPR2 signaling

FEBS Open Bio, EarlyView.
Elevated DDX3X expression led to downregulation of BMPR2, a key regulator of endothelial homeostasis and function. Our co‐immunoprecipitation assays further demonstrated a molecular interaction between DDX3X and BMPR2. Notably, DDX3X promoted lysosomal degradation of BMPR2, thereby impairing its downstream signaling and facilitating endothelial‐to ...
Yu Zhang, Jing Wang, De‐Hui Qian, Yang‐Fan Lv, Tian‐Le Cheng, Da‐Peng Wang, Jing Zhang, Ye Fan   +7 more
wiley   +1 more source

Beta blockers and hypertrophic obstructive cardiomyopathy: a systematic review and meta-analysis. [PDF]

Open Heart
Smith AJ, Cromie AMM, Bowles L, Anderson T, Panchal J, Walters B.   +5 more
europepmc   +1 more source

Beta-blockers in patients with refractory ascites: To treat or not to treat. That is the question? But, what is the answer? [PDF]

, 2012
Mónica Guevara, Roberto J. Groszmann, Yasuko Iwakiri, Tamar H. Taddei   +3 more
openalex   +1 more source

ATP13A2 is involved in intracellular polyamine transport in lung epithelial cells

FEBS Open Bio, EarlyView.
Spermidine transport in lung epithelial cells involves the polyamine transporter ATP13A2. Cell proliferation is associated with the upregulation of ATP13A2. Polyamines are present in all living cells and are implicated in various crucial cellular processes such as proliferation, apoptosis and autophagy.
Yuta Hatori, Kohei Kawabata, Takanori Kubo, Takeo Kitazawa, Sae Kanai, Madoka Iwashita, Ami Hayashi, Hiroyuki Nishi, Mikihisa Takano   +8 more
wiley   +1 more source

Target Trial Emulation of Beta-Blockers After Diagnosis of Colorectal Polyps-Beneficial in Women. [PDF]

United European Gastroenterol J
Emilsson L, Song M, Petito LC, Ludvigsson JF.   +3 more
europepmc   +1 more source

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

Beta-Blockers in Stable Coronary Artery Disease: A Systematic Review and Meta-Analysis of Observational Studies. [PDF]

Rev Cardiovasc Med
Liu JX, Zheng SY, Guo F, He CH, Lin J, Fu H, Du X, Dong JZ.   +7 more
europepmc   +1 more source

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

The Therapeutic Potential of Propranolol and Other Beta-Blockers in Hyperthyroidism. [PDF]

Int J Mol Sci
Szybiak-Skora W, Miedziaszczyk M, Szałek E, Lacka K.   +3 more
europepmc   +1 more source

Therapeutic Role of Beta-blockers in Hypertension: A Pragmatic Reappraisal

, 2016
Soumitra Kumar
openalex   +1 more source